Mechanisms of Toxoplasma gondii persistence and latency

WJ Sullivan Jr, V Jeffers - FEMS microbiology reviews, 2012 - academic.oup.com
Toxoplasma gondii is an obligate intracellular protozoan parasite that causes opportunistic
disease, particularly in immunocompromised individuals. Central to its transmission and …

The development and biology of bradyzoites of Toxoplasma gondii

LM Weiss, K Kim - Frontiers in bioscience: a journal and virtual …, 2000 - pmc.ncbi.nlm.nih.gov
Toxoplasma gondii is a protozoan parasite of mammals and birds that is an important
human pathogen. Infection with this Apicomplexan parasite results in its dissemination …

Toxoplasma gondii: determinants of tachyzoite to bradyzoite conversion

S Skariah, MK McIntyre, DG Mordue - Parasitology research, 2010 - Springer
Apicomplexa are primarily obligate intracellular protozoa that have evolved complex
developmental stages important for pathogenesis and transmission. Toxoplasma gondii …

Toxoplasma gondii Asexual Development: Identification of Developmentally Regulated Genes and Distinct Patterns of Gene Expression

MD Cleary, U Singh, IJ Blader, JL Brewer… - Eukaryotic …, 2002 - journals.asm.org
Asexual development in Toxoplasma gondii is a vital aspect of the parasite's life cycle,
allowing transmission and avoidance of the host immune response. Differentiation of rapidly …

Expression of Indoleamine 2,3-Dioxygenase, Tryptophan Degradation, and Kynurenine Formation during In Vivo Infection with Toxoplasma gondii: Induction by …

NM Silva, CV Rodrigues, MM Santoro… - Infection and …, 2002 - journals.asm.org
ABSTRACT The induction of indoleamine 2, 3-dioxygenase (INDO) expression and the
tryptophan (Trp)-kynurenine (Kyn) metabolic pathway during in vivo infection with …

Intracellular protozoan parasites of humans: the role of molecular chaperones in development and pathogenesis

A Shonhai, AG Maier, JM Przyborski… - Protein and peptide …, 2011 - ingentaconnect.com
Certain kinetoplastid (Leishmania spp. and Trypanosoma cruzi) and apicomplexan
parasites (Plasmodium falciparum and Toxoplasma gondii) are capable of invading human …

Genetic analysis of tachyzoite to bradyzoite differentiation mutants in Toxoplasma gondii reveals a hierarchy of gene induction

U Singh, JL Brewer, JC Boothroyd - Molecular microbiology, 2002 - Wiley Online Library
Developmental switching in Toxoplasma gondii, from the virulent tachyzoite to the relatively
quiescent bradyzoite stage, is responsible for disease propagation and reactivation. We …

Plasmodial heat shock proteins: targets for chemotherapy

A Shonhai - FEMS immunology & medical microbiology, 2010 - academic.oup.com
Heat shock proteins act as molecular chaperones, facilitating protein folding in cells of living
organisms. Their role is particularly important in parasites because environmental changes …

Toxoplasma gondii Hsp90 is a potential drug target whose expression and subcellular localization are developmentally regulated

PC Echeverria, M Matrajt, OS Harb, MP Zappia… - Journal of molecular …, 2005 - Elsevier
Two replicative forms characterize the asexual cycle of the protozoan parasite Toxoplasma
gondii: rapidly growing tachyzoites and slowly dividing encysted bradyzoites. The …

Effective factors in the pathogenesis of Toxoplasma gondii

T Nayeri, S Sarvi, A Daryani - Heliyon, 2024 - cell.com
Toxoplasma gondii (T. gondii) is a cosmopolitan protozoan parasite in humans and animals.
It infects about 30% of the human population worldwide and causes potentially fatal …