Therapeutic peptides: current applications and future directions

L Wang, N Wang, W Zhang, X Cheng, Z Yan… - Signal transduction and …, 2022 - nature.com
Peptide drug development has made great progress in the last decade thanks to new
production, modification, and analytic technologies. Peptides have been produced and …

[HTML][HTML] Mechanisms of SARS-CoV-2 entry into cells

CB Jackson, M Farzan, B Chen, H Choe - Nature reviews Molecular …, 2022 - nature.com
The unprecedented public health and economic impact of the COVID-19 pandemic caused
by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been …

The Huanan Seafood Wholesale Market in Wuhan was the early epicenter of the COVID-19 pandemic

M Worobey, JI Levy, L Malpica Serrano… - Science, 2022 - science.org
Understanding how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
emerged in 2019 is critical to preventing future zoonotic outbreaks before they become the …

Bat coronaviruses related to SARS-CoV-2 and infectious for human cells

S Temmam, K Vongphayloth, E Baquero, S Munier… - Nature, 2022 - nature.com
The animal reservoir of SARS-CoV-2 is unknown despite reports of SARS-CoV-2-related
viruses in Asian Rhinolophus bats,,–, including the closest virus from R. affinis, RaTG13 …

The molecular epidemiology of multiple zoonotic origins of SARS-CoV-2

JE Pekar, A Magee, E Parker, N Moshiri, K Izhikevich… - Science, 2022 - science.org
Understanding the circumstances that lead to pandemics is important for their prevention.
We analyzed the genomic diversity of severe acute respiratory syndrome coronavirus 2 …

The emergence, genomic diversity and global spread of SARS-CoV-2

J Li, S Lai, GF Gao, W Shi - Nature, 2021 - nature.com
Since the first cases of COVID-19 were documented in Wuhan, China in 2019, the world has
witnessed a devastating global pandemic, with more than 238 million cases, nearly 5 million …

Divergent SARS-CoV-2 variant emerges in white-tailed deer with deer-to-human transmission

B Pickering, O Lung, F Maguire, P Kruczkiewicz… - Nature …, 2022 - nature.com
Wildlife reservoirs of broad-host-range viruses have the potential to enable evolution of viral
variants that can emerge to infect humans. In North America, there is phylogenomic …

SARS-CoV-2 infection in free-ranging white-tailed deer

VL Hale, PM Dennis, DS McBride, JM Nolting… - Nature, 2022 - nature.com
Humans have infected a wide range of animals with SARS-CoV-2,,,–, but the establishment
of a new natural animal reservoir has not been observed. Here we document that free …

Structural biology of SARS-CoV-2: open the door for novel therapies

W Yan, Y Zheng, X Zeng, B He, W Cheng - Signal Transduction and …, 2022 - nature.com
Abstract Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the causative
agent of the pandemic disease COVID-19, which is so far without efficacious treatment. The …

[HTML][HTML] The origins of SARS-CoV-2: A critical review

EC Holmes, SA Goldstein, AL Rasmussen… - Cell, 2021 - cell.com
Since the first reports of a novel severe acute respiratory syndrome (SARS)-like coronavirus
in December 2019 in Wuhan, China, there has been intense interest in understanding how …