A review of phospholipid encapsulated ultrasound contrast agent microbubble physics

B Helfield - Ultrasound in medicine & biology, 2019 - Elsevier
Ultrasound contrast agent microbubbles have expanded the utility of biomedical ultrasound
from anatomic imaging to the assessment of microvascular blood flow characteristics and …

20 years of ultrasound contrast agent modeling

T Faez, M Emmer, K Kooiman… - IEEE transactions on …, 2012 - ieeexplore.ieee.org
The merits of ultrasound contrast agents (UCAs) were already known in the 1960s. It was,
however, not until the 1990s that UCAs were clinically approved and marketed. In these …

[HTML][HTML] The influence of inter-bubble spacing on the resonance response of ultrasound contrast agent microbubbles

H Yusefi, B Helfield - Ultrasonics Sonochemistry, 2022 - Elsevier
Ultrasound-driven microbubbles, typically between 1 and 8 µm in diameter, are resonant
scatterers that are employed as diagnostic contrast agents and emerging as potentiators of …

Evaluating the safety profile of focused ultrasound and microbubble-mediated treatments to increase blood-brain barrier permeability

D McMahon, C Poon, K Hynynen - Expert opinion on drug delivery, 2019 - Taylor & Francis
Introduction: Treatment of several diseases of the brain are complicated by the presence of
the skull and the blood-brain barrier (BBB). Focused ultrasound (FUS) and microbubble …

Characterization of contrast agent microbubbles for ultrasound imaging and therapy research

H Mulvana, RJ Browning, Y Luan… - IEEE transactions on …, 2016 - ieeexplore.ieee.org
The high efficiency with which gas microbubbles can scatter ultrasound compared with the
surrounding blood pool or tissues has led to their widespread employment as contrast …

Lipid shedding from single oscillating microbubbles

Y Luan, G Lajoinie, E Gelderblom, I Skachkov… - Ultrasound in medicine …, 2014 - Elsevier
Lipid-coated microbubbles are used clinically as contrast agents for ultrasound imaging and
are being developed for a variety of therapeutic applications. The lipid encapsulation and …

Nonlinear resonance behavior and linear shell estimates for Definity™ and MicroMarker™ assessed with acoustic microbubble spectroscopy

BL Helfield, DE Goertz - The Journal of the Acoustical Society of …, 2013 - pubs.aip.org
There is a growing interest in microbubble based ultrasound contrast imaging applications
in the 5–15 MHz range. In this study, individual microbubbles were insonified at low …

Experimental and numerical evidence of intensified non-linearity at the microscale: The lipid coated acoustic bubble

AJ Sojahrood, H Haghi, TM Porter, R Karshafian… - Physics of …, 2021 - pubs.aip.org
A lipid coated bubble (LCB) oscillator is a very interesting non-smooth oscillator with many
important applications ranging from industry and chemistry to medicine. However, due to the …

Targeted ultrasound contrast agents for ultrasound molecular imaging and therapy

T van Rooij, V Daeichin, I Skachkov… - International journal …, 2015 - Taylor & Francis
Ultrasound contrast agents (UCAs) are used routinely in the clinic to enhance contrast in
ultrasonography. More recently, UCAs have been functionalised by conjugating ligands to …

Non-linear response and viscoelastic properties of lipid-coated microbubbles: DSPC versus DPPC

T van Rooij, Y Luan, G Renaud… - Ultrasound in medicine …, 2015 - Elsevier
For successful in vivo contrast-enhanced ultrasound imaging (CEUS) and ultrasound
molecular imaging, detailed knowledge of stability and acoustical properties of the …