Double‐strand breaks (DSBs) are the most harmful DNA lesions, with a strong impact on cell
proliferation and genome integrity. Depending on cell cycle stage, DSBs are preferentially …

Antibodies that gain specificity by a large insert encoding for an extra domain were
described for the first time in 2016. In malaria-exposed individuals, an exon deriving from the …

Mitochondria serve as the cellular powerhouse, and their distinct DNA makes them a
prospective target for gene editing to treat genetic disorders. However, the impact of genome …

In metazoans mitochondrial DNA (mtDNA) or retrotransposon cDNA released to cytoplasm
are degraded by nucleases to prevent sterile inflammation. It remains unknown whether …

Alternative lengthening of telomeres (ALT) is a telomere maintenance mechanism mediated
by break-induced replication, evident in approximately 15% of human cancers. A …

Formation of templated insertions at DNA double-strand breaks (DSBs) is very common in
cancer cells. The mechanisms and enzymes regulating these events are largely unknown …

In a recent article published in Nature, Arnould and colleagues reveal that DNA double-
stranded breaks (DSBs) strengthen chromatin compartmentalization near the breaks. They …

In metazoans release of mitochondrial DNA or retrotransposon cDNA to cytoplasm can
cause sterile inflammation and disease 1. Cytoplasmic nucleases degrade these DNA …

N-Nitrosamines, known as drug impurities and suspected carcinogens, have drawn
significant public concern. In response to drug regulatory needs, the European Medicines …

Alternative Lengthening of Telomeres (ALT) is a telomere maintenance mechanism
mediated by break-induced replication (BIR), evident in approximately 15% of human …