Retinitis pigmentosa (RP) comprises a group of inherited retinal dystrophies characterized
by the degeneration of rod photoreceptors, followed by the degeneration of cone …

X-linked retinopathies represent a significant proportion of monogenic retinal disease. They
include progressive and stationary conditions, with and without syndromic features. Many …

Retinal gene therapy is increasingly recognized as a novel molecular intervention that has
huge potential in treating common causes of blindness, the majority of which have a genetic …

Purpose Safe and reproducible delivery of gene therapy vector into the subretinal space is
essential for successful targeting of the retinal pigment epithelium (RPE) and …

Purpose: Widespread adoption of optical coherence tomography has revolutionized the
diagnosis and management of retinal disease. If the cellular and subcellular sources of …

Purpose To describe in detail the central retinal structure of a large group of patients with
choroideremia (CHM). Design A prospective, cross-sectional, descriptive study. Participants …

Purpose: Centripetal retinal degeneration in choroideremia (CHM) leads to early visual field
restriction and late central vision loss. The latter marks an acute decline in quality of life but …

Even though the very thought of an injection into the eye may be frightening, an estimated 6
million intravitreal (IVT) injections were made in the USA during 2016. With the introduction …

Choroideremia is an X-linked inherited chorioretinal dystrophy leading to blindness by late
adulthood. Choroideremia is caused by mutations in the CHM gene which encodes Rab …

Purpose To document outer retinal tubulation (ORT) formation in advanced retinal disorders.
Design Retrospective, observational study. Participants Consecutive cases with retinal …