With the increase in the ageing population, neurodegenerative disease is devastating to
families and poses a huge burden on society. The brain and spinal cord are extraordinarily …

Drosophila melanogaster provides a powerful genetic model system in which to investigate
the molecular mechanisms underlying neurodegenerative diseases. In this review, we …

A proline to serine substitution at position 56 in the gene encoding vesicle-associated
membrane protein-associated protein B (VAPB) causes some dominantly inherited familial …

The use of Drosophila in neurodegenerative disease research has contributed to the
identification of modifier genes for the pathology. The basis for neurodegenerative disease …

Human neurodegenerative diseases are devastating illnesses that predominantly affect
elderly people. The majority of the diseases are associated with pathogenic oligomers from …

Amyotrophic lateral sclerosis (ALS) is an incurable neuromuscular disease that leads to a
profound loss of life quality and premature death. Around 10% of the cases are inherited and …

The fruit fly, Drosophila melanogaster, has a long and rich history as an important model
organism for biologists. In particular, study of the fruit fly has been essential to much of our …

Vesicle-associated membrane protein (VAMP)-associated proteins (VAPs) are ubiquitous
ER-resident tail-anchored membrane proteins in eukaryotic cells. Their N-terminal major …

Following the mutation screening of genes known to cause amyotrophic lateral sclerosis
(ALS) in index cases from 107 familial ALS (FALS) kindred, a point mutation was identified in …

Neuromuscular junction assembly and plasticity during embryonic, postnatal, and adult life
are tightly regulated by the continuous cross-talk among motor nerve endings, muscle fibers …