Applications of Raman spectroscopy in the development of cell therapies: state of the art and future perspectives

S Rangan, HG Schulze, MZ Vardaki, MW Blades… - Analyst, 2020 - pubs.rsc.org
Therapies based on injecting living cells into patients offer a huge potential to cure many
degenerative and deadly diseases, with hundreds of clinical trials ongoing. Due to their …

[HTML][HTML] Particles in biopharmaceutical formulations, part 2: an update on analytical techniques and applications for therapeutic proteins, viruses, vaccines and cells

A Roesch, S Zölls, D Stadler, C Helbig… - Journal of …, 2022 - Elsevier
Particles in biopharmaceutical formulations remain a hot topic in drug product development.
With new product classes emerging it is crucial to discriminate particulate active …

Noninvasive detection of macrophage activation with single-cell resolution through machine learning

N Pavillon, AJ Hobro, S Akira… - Proceedings of the …, 2018 - National Acad Sciences
We present a method enabling the noninvasive study of minute cellular changes in
response to stimuli, based on the acquisition of multiple parameters through label-free …

Quantitative phase microscopy for evaluation of intestinal inflammation and wound healing utilizing label-free biophysical markers

D Bettenworth, A Bokemeyer, C Poremba, NS Ding… - 2018 - digitum.um.es
Inflammatory bowel diseases (IBD) are inflammatory disorders of the gastrointestinal tract
characterized by a chronic relapsing disease course. As uncontrolled intestinal inflammation …

Detection and differentiation of bacterial and fungal infection of neutrophils from peripheral blood using Raman spectroscopy

N Arend, A Pittner, A Ramoji, AS Mondol… - Analytical …, 2020 - ACS Publications
Neutrophils are important cells of the innate immune system and the major leukocyte
subpopulation in blood. They are responsible for recognizing and neutralizing invading …

Raman microscopy: progress in research on cancer cell sensing

S Elumalai, S Managó, AC De Luca - Sensors, 2020 - mdpi.com
In the last decade, Raman Spectroscopy (RS) was demonstrated to be a label-free, non-
invasive and non-destructive optical spectroscopy allowing the improvement in diagnostic …

Investigation of refractive index dynamics during in vitro embryo development using off-axis digital holographic microscopy

GO Dwapanyin, DJX Chow, TCY Tan… - Biomedical Optics …, 2023 - opg.optica.org
Embryo quality is a crucial factor affecting live birth outcomes. However, an accurate
diagnostic for embryo quality remains elusive in the in vitro fertilization clinic. Determining …

Flow cytometry and micro-Raman spectroscopy: Identification of hemocyte populations in the mussel Mytilus galloprovincialis (Bivalvia: Mytilidae) from Faro Lake and …

V Parrino, G Costa, C Cannavà, E Fazio… - Fish & Shellfish …, 2019 - Elsevier
Immunological and structural characteristics of hemocyte populations in the mussel Mytilus
galloprovincialis (Bivalvia: Mytilidae), going from two different Sicilian habitats (Faro Lake …

In vivo optical molecular imaging of inflammation and immunity

N Liu, X Chen, MA Kimm, M Stechele, X Chen… - Journal of Molecular …, 2021 - Springer
Inflammation is the phenotypic form of various diseases. Recent development in molecular
imaging provides new insights into the diagnostic and therapeutic evaluation of different …

Decoding optical data with machine learning

J Fang, A Swain, R Unni, Y Zheng - Laser & photonics reviews, 2021 - Wiley Online Library
Optical spectroscopy and imaging techniques play important roles in many fields such as
disease diagnosis, biological study, information technology, optical science, and materials …