Understanding how human genetics influence infectious disease susceptibility offers the
opportunity for new insights into pathogenesis, potential drug targets, risk stratification …

Studies in diverse biological systems have indicated that host–parasite co-evolution is
responsible for the extraordinary genetic diversity seen in some genomic regions, such as …

Personalized genome sequencing has revealed millions of genetic differences between
individuals, but our understanding of their clinical relevance remains largely incomplete. To …

The current rate of species extinction is rapidly approaching unprecedented highs, and life
on Earth presently faces a sixth mass extinction event driven by anthropogenic activity …

The ancient biological'arms race'between microbial pathogens and humans has shaped
genetic variation in modern populations, and this has important implications for the growing …

Balancing selection is an evolutionary process that maintains genetic polymorphisms at
selected loci and strongly reduces the likelihood of allele fixation. When allelic …

In many species, genomic data have revealed pervasive adaptive evolution indicated by the
fixation of beneficial alleles. However, when selection pressures are highly variable along a …

Detection of recent natural selection is a challenging problem in population genetics. Here
we introduce the singleton density score (SDS), a method to infer very recent changes in …

The complex correlation structure of a collection of orthologous DNA sequences is uniquely
captured by the “ancestral recombination graph”(ARG), a complete record of coalescence …

Malaria has been the pre-eminent cause of early mortality in many parts of the world
throughout much of the last five thousand years and, as a result, it is the strongest force for …