Adipose tissue-derived mesenchymal stem cells (ASCs) are adult stem cells, endowed with
self-renewal, multipotent capacities, and immunomodulatory properties, as mesenchymal …

Beta cells adapt their function to respond to fluctuating glucose concentrations and variable
insulin demand. The highly specialized beta cells have well-established endoplasmic …

To understand features of human obesity and type 2 diabetes mellitus (T2D) that can be
recapitulated in the mouse, we compared C57BL/6J mice fed a Western‐style diet (WD) to …

The inflammatory eye disease Graves' orbitopathy (GO) is the main complication of
autoimmune Graves' disease. In previous studies we have shown that hypoxia plays an …

Proinflammatory cytokines impact islet β-cell mass and function by altering the
transcriptional activity within pancreatic β-cells, producing increases in intracellular nitric …

Nasopharyngeal carcinoma (NPC) is a unique EBV‐associated subtype of head and neck
cancer, which has the highest incidence in Southern China and eastern South Asia. The …

Objective Pancreatic tissue, and islets in particular, are enriched in expression of the
interleukin-1 receptor type I (IL-1R). Because of this enrichment, islet β-cells are exquisitely …

A major and irreversible complication of diabetes is diabetic peripheral neuropathy (DPN),
which can lead to significant disability and decreased quality of life. Prior work demonstrates …

CC chemoattractant cytokine (chemokine) receptor 6 (CCR6) and its exclusive binding
molecule CCL20 is an extremely important chemokine receptor-ligand pair which controls …

Objectives Fatty acid oxidation (FAO) and glycolysis have been implicated in immune
regulation and activation of macrophages. However, investigation of human monocyte …