The older adult brain is less modular, more integrated, and less efficient at rest: A systematic review of large‐scale resting‐state functional brain networks in aging

HA Deery, R Di Paolo, C Moran, GF Egan… - …, 2023 - Wiley Online Library
The literature on large‐scale resting‐state functional brain networks across the adult
lifespan was systematically reviewed. Studies published between 1986 and July 2021 were …

Get a grip: individual variations in grip strength are a marker of brain health

RG Carson - Neurobiology of aging, 2018 - Elsevier
Demonstrations that grip strength has predictive power in relation to a range of health
conditions—even when these are assessed decades later—has motivated claims that hand …

Associations between cardiovascular risk, structural brain changes, and cognitive decline

R Song, H Xu, CS Dintica, KY Pan, X Qi… - Journal of the American …, 2020 - jacc.org
Background The impact of cardiovascular risk burden on cognitive trajectories and brain
structure changes remains unclear. Objectives This study aimed to examine whether …

The effect of aging on resting state connectivity of predefined networks in the brain

E Varangis, CG Habeck, QR Razlighi… - Frontiers in aging …, 2019 - frontiersin.org
Recent studies have found a deleterious effect of age on a wide variety of measures of
functional connectivity, and some hints at a relationship between connectivity at rest and …

The disconnected brain and executive function decline in aging

AM Fjell, MH Sneve, H Grydeland, AB Storsve… - Cerebral …, 2017 - academic.oup.com
Higher order speeded cognitive abilities depend on efficient coordination of activity across
the brain, rendering them vulnerable to age reductions in structural and functional brain …

[HTML][HTML] Longitudinal association between hippocampus atrophy and episodic-memory decline

T Gorbach, S Pudas, A Lundquist, G Orädd… - Neurobiology of …, 2017 - Elsevier
There is marked variability in both onset and rate of episodic-memory decline in aging.
Structural magnetic resonance imaging studies have revealed that the extent of age-related …

Human connectomics across the life span

XN Zuo, Y He, RF Betzel, S Colcombe, O Sporns… - Trends in cognitive …, 2017 - cell.com
Connectomics has enhanced our understanding of neurocognitive development and decline
by the integration of network sciences into studies across different stages of the human life …

Fitness, but not physical activity, is related to functional integrity of brain networks associated with aging

MW Voss, TB Weng, AZ Burzynska, CN Wong… - Neuroimage, 2016 - Elsevier
Greater physical activity and cardiorespiratory fitness are associated with reduced age-
related cognitive decline and lower risk for dementia. However, significant gaps remain in …

[HTML][HTML] A systematic review of the impacts of intergenerational engagement on older adults' cognitive, social, and health outcomes

A Krzeczkowska, DM Spalding, WJ McGeown… - Ageing Research …, 2021 - Elsevier
Background Intergenerational engagement could benefit health and wellbeing within an
ageing population. This systematic review evaluated the impacts of intergenerational …

Signatures of white-matter microstructure degradation during aging and its association with cognitive status

A Coelho, HM Fernandes, R Magalhães, PS Moreira… - Scientific reports, 2021 - nature.com
Previous studies have shown an association between cognitive decline and white matter
integrity in aging. This led to the formulation of a “disconnection hypothesis” in the aging …