The cGAS-STING pathway in viral infections: a promising link between inflammation, oxidative stress and autophagy

K Zhang, Q Huang, X Li, Z Zhao, C Hong… - Frontiers in …, 2024 - frontiersin.org
The host defence responses play vital roles in viral infection and are regulated by complex
interactive networks. The host immune system recognizes viral pathogens through the …

Protein arginine methylation in viral infection and antiviral immunity

K Zheng, S Chen, Z Ren… - International journal of …, 2023 - pmc.ncbi.nlm.nih.gov
Protein arginine methyltransferase (PRMT)-mediated arginine methylation is an important
post-transcriptional modification that regulates various cellular processes including …

Interferon response and epigenetic modulation by SMARCA4 mutations drive ovarian tumor immunogenicity

MN Brodeur, H Dopeso, Y Zhu, ALF Longhini… - Science …, 2024 - science.org
Cell-intrinsic mechanisms of immunogenicity in ovarian cancer (OC) are not well
understood. Damaging mutations in the SWI/SNF chromatin remodeling complex, such as …

SARS-CoV-2 ORF8 as a modulator of cytokine induction: evidence and search for molecular mechanisms

MI Móvio, GWC Almeida, IGL Martines… - Viruses, 2024 - mdpi.com
Severe cases of SARS-CoV-2 infection are characterized by an immune response that leads
to the overproduction of pro-inflammatory cytokines, resulting in lung damage …

SARS‐CoV‐2, periodontal pathogens, and host factors: The trinity of oral post‐acute sequelae of COVID‐19

J Schwartz, KJ Capistrano, J Gluck… - Reviews in Medical …, 2024 - Wiley Online Library
COVID‐19 as a pan‐epidemic is waning but there it is imperative to understand virus
interaction with oral tissues and oral inflammatory diseases. We review periodontal disease …

Universal STING Pathway-Activating Complexes Counteract Viral Immune Evasion and Boost Antiviral Responses

X Liu, J **e, H **ao, C Zhang, W Li, M Zhou, Y Zeng… - ACS …, 2025 - ACS Publications
Viruses have evolved multiple mechanisms to counteract the stimulator of the interferon
genes (STING) pathway, resulting in the suppression of antiviral responses. Accordingly, in …

Exosome co-delivery of a STING agonist augments immunogenicity elicited by CVB3 VP1 vaccine via promoting antigen cross-presentation of CD8+ DCs

C Zhang, Q Cao, Y Li, J Lu, S **ong, Y Yue - International Journal of …, 2024 - Elsevier
The induction of a robust CD8+ T cell response is critical for the success of an antiviral
vaccine. In this study, we incorporated a STING agonist (SA) 2′ 3'-cGAMP into a previously …

Bat STING drives IFN-beta production in anti-RNA virus innate immune response

F Fu, Q Shao, J Zhang, J Wang, Z Wang, J Ma… - Frontiers in …, 2023 - frontiersin.org
The ability of stimulator of interferon genes (STING) to activate interferon (IFN) responses
during RNA virus infection has been demonstrated in different mammalian cells. Despite …

Multifaceted activation of STING axis upon Nipah and measles virus-induced syncytia formation

L Amurri, C Dumont, R Pelissier, O Reynard… - PLoS …, 2024 - journals.plos.org
Activation of the DNA-sensing STING axis by RNA viruses plays a role in antiviral response
through mechanisms that remain poorly understood. Here, we show that the STING pathway …

COVID-19. Biology, pathophysiology, and immunology: a pathologist view

M Chilosi, C Doglioni, C Ravaglia, S Piciucchi… - …, 2023 - pmc.ncbi.nlm.nih.gov
Even if the SARS-CoV-2 pandemic has been declared over, several risks and clinical
problems remain to be faced, including long-COVID sequelae and possible outbreaks of …