Tuberculosis remains the leading cause of death from an infectious disease worldwide.
Early and accurate diagnosis and detection of drug-sensitive and drug-resistant tuberculosis …

Millions of cases of tuberculosis (TB) go undiagnosed each year. Better diagnostic tools are
urgently needed. Biomarker-based or multiple marker biosignature-based tests, ideally …

Background Active pulmonary tuberculosis is difficult to diagnose and treatment response is
difficult to effectively monitor. A WHO consensus statement has called for new non-sputum …

The epidemiology of infectious causes of meningitis in sub-Saharan Africa is not well
understood, and a common cause of meningitis in this region, Mycobacterium tuberculosis …

Background The World Health Organization (WHO) and Foundation for Innovative New
Diagnostics (FIND) have published target product profiles (TPPs) calling for non-sputum …

Immunology is a central theme when it comes to tuberculosis (TB). The outcome of human
infection with Mycobacterium tuberculosis is dependent on the ability of the immune …

Introduction Host blood transcriptomic biomarkers have potential as rapid point-of-care
triage, diagnostic, and predictive tests for Tuberculosis disease. We aimed to summarise the …

Background The World Health Organization recommends standardised treatment durations
for patients with tuberculosis (TB). We identified and validated a host-RNA signature as a …

Background Multiple host blood transcriptional signatures have been developed as non-
sputum triage tests for tuberculosis (TB). We aimed to compare the diagnostic performance …

Blood transcriptional signatures are promising for tuberculosis (TB) diagnosis but have not
been evaluated among US patients. To be used clinically, transcriptional classifiers need …