Reactive oxygen species in metabolic and inflammatory signaling
Reactive oxygen species (ROS) are well known for their role in mediating both physiological
and pathophysiological signal transduction. Enzymes and subcellular compartments that …
and pathophysiological signal transduction. Enzymes and subcellular compartments that …
Vascular smooth muscle cells in atherosclerosis
GL Basatemur, HF Jørgensen, MCH Clarke… - Nature reviews …, 2019 - nature.com
Vascular smooth muscle cells (VSMCs) are a major cell type present at all stages of an
atherosclerotic plaque. According to the 'response to injury'and 'vulnerable …
atherosclerotic plaque. According to the 'response to injury'and 'vulnerable …
Protein misfolding in the endoplasmic reticulum as a conduit to human disease
In eukaryotic cells, the endoplasmic reticulum is essential for the folding and trafficking of
proteins that enter the secretory pathway. Environmental insults or increased protein …
proteins that enter the secretory pathway. Environmental insults or increased protein …
Cholesterol-induced phenotypic modulation of smooth muscle cells to macrophage/fibroblast–like cells is driven by an unfolded protein response
Objective: Vascular smooth muscle cells (SMCs) dedifferentiate and initiate expression of
macrophage markers with cholesterol exposure. This phenotypic switching is dependent on …
macrophage markers with cholesterol exposure. This phenotypic switching is dependent on …
[HTML][HTML] ER stress transforms random olfactory receptor choice into axon targeting precision
HJ Shayya, JK Kahiapo, R Duffié, KS Lehmann… - Cell, 2022 - cell.com
Olfactory sensory neurons (OSNs) convert the stochastic choice of one of> 1,000 olfactory
receptor (OR) genes into precise and stereotyped axon targeting of OR-specific glomeruli in …
receptor (OR) genes into precise and stereotyped axon targeting of OR-specific glomeruli in …
Chop/Ddit3 depletion in β cells alleviates ER stress and corrects hepatic steatosis in mice
Type 2 diabetes (T2D) is a metabolic disorder characterized by hyperglycemia,
hyperinsulinemia, and insulin resistance (IR). During the early phase of T2D, insulin …
hyperinsulinemia, and insulin resistance (IR). During the early phase of T2D, insulin …
Role of endoplasmic reticulum stress in atherosclerosis and its potential as a therapeutic target
S Yang, M Wu, X Li, R Zhao, Y Zhao… - … Medicine and Cellular …, 2020 - Wiley Online Library
Endoplasmic reticulum (ER) stress is closely associated with atherosclerosis and related
cardiovascular diseases (CVDs). It occurs due to various pathological factors that interfere …
cardiovascular diseases (CVDs). It occurs due to various pathological factors that interfere …
RGC-specific ATF4 and/or CHOP deletion rescues glaucomatous neurodegeneration and visual function
Endoplasmic reticulum (ER) stress has been linked with various acute and chronic
neurodegenerative diseases. We previously found that optic nerve (ON) injury and diseases …
neurodegenerative diseases. We previously found that optic nerve (ON) injury and diseases …
Smooth muscle α-actin missense variant promotes atherosclerosis through modulation of intracellular cholesterol in smooth muscle cells
Abstract Aims The variant p. Arg149Cys in ACTA2, which encodes smooth muscle cell
(SMC)-specific α-actin, predisposes to thoracic aortic disease and early onset coronary …
(SMC)-specific α-actin, predisposes to thoracic aortic disease and early onset coronary …
[HTML][HTML] Regulation of Nox enzymes expression in vascular pathophysiology: focusing on transcription factors and epigenetic mechanisms
NADPH oxidases (Nox) represent a family of hetero-oligomeric enzymes whose exclusive
biological function is the generation of reactive oxygen species (ROS). Nox-derived ROS are …
biological function is the generation of reactive oxygen species (ROS). Nox-derived ROS are …