Cell type-and differentiation-specific gene expression is precisely controlled by genomic non-
coding regulatory elements (NCREs), which include promoters, enhancers, silencers and …

Retinoic acid (RA) signalling has a central role during vertebrate development. RA
synthesized in specific locations regulates transcription by interacting with nuclear RA …

Histone deacetylases (HDACs) are enzymes that catalyze the removal of acetyl functional
groups from the lysine residues of both histone and nonhistone proteins. In humans, there …

Cellular actions of thyroid hormone may be initiated within the cell nucleus, at the plasma
membrane, in cytoplasm, and at the mitochondrion. Thyroid hormone nuclear receptors …

During the past decade there has been a substantial advance in our understanding of
estrogen signaling both from a clinical as well as a preclinical perspective. Estrogen …

The selective estrogen-receptor modulators, or SERMs, chemically diverse nonsteroid
compounds, have tertiary structures that permit binding to the estrogen receptor. These …

Thyroid hormone (TH) plays a critical role in maintaining metabolic homeostasis throughout
life. It is well known that the liver and thyroid are intimately linked, with TH playing important …

The nuclear receptor (NR) superfamily of transcription factors regulates gene expression in
response to endocrine signaling, and recruitment of coregulators affords these receptors …

Transcriptional activation of a gene involves an orchestrated recruitment of components of
the basal transcription machinery and intermediate factors, concomitant with an alteration in …

Selective estrogen receptor modulators (SERMs) are a diverse group of nonsteroidal
compounds that function as agonists or antagonists for estrogen receptors (ERs) in a target …