Newly synthesized transmembrane proteins undergo a series of steps to ensure that only
the required amount of correctly folded protein is localized to the membrane. The regulation …

Members of the HECT family of E3 ubiquitin-protein ligases are characterized by a C-
terminal HECT domain that catalyzes the covalent attachment of ubiquitin to substrate …

When ubiquitin (Ub) is attached to membrane proteins on the plasma membrane, it directs
them through a series of sorting steps that culminate in their delivery to the lumen of the …

Ubiquitination plays a crucial role in regulating proteins post-translationally. The focus of this
review is on NEDD4, the founding member of the NEDD4 family of ubiquitin ligases that is …

Although iron is vital, its free form is likely to be involved in oxidation-reduction reactions,
leading to the formation of free radicals and oxidative stress. Living organisms have …

Abstract Hypoxia-inducible factor (HIF), a key modulator of the transcriptional response to
hypoxia, is increased in colon cancer. However, the role of HIF in colon carcinogenesis in …

INTRODUCTION Foodborne infections represent a serious and increasing human health
problem while at the same time the incidence and prevalence of colitis and the inflammatory …

Iron homeostasis is an essential prerequisite for metabolic and neurological functions
throughout the healthy human life, with a dynamic interplay between intracellular and …

Abstract Divalent metal-ion transporter-1 (DMT1) is a widely expressed, iron-preferring
membrane transport protein. Animal models establish that DMT1 plays indispensable roles …

Hepcidin regulates iron homeostasis by controlling the level of ferroportin, the only
membrane channel that facilitates export of iron from within cells. Binding of hepcidin to …