The AGC family of serine/threonine kinases (PKA, PKG, PKC) includes more than 60
members that are critical regulators of numerous cellular functions, including cell cycle and …

Following the initial identification o~ protein kinase C (PKC) by Nishizuka arid co-workers in
the late seventies, a wealth of information on this protein kinase has accumulated. Perhaps …

Phorbol ester treatment of quiescent Swiss 3T3 cells leads to cell proliferation, a response
thought to be mediated by protein kinase C (PKC), the major cellular receptor for this class of …

Protein kinase C (PKC), which comprises 11 closely related isoforms, has been implicated in
a wide variety of cellular processes, such as growth, differentiation, secretion, apoptosis and …

Current cancer therapies are highly toxic and often nonspecific. A potentially less toxic
approach to treating this prevalent disease employs agents that modify cancer cell …

Granulocytes and monocytes develop from a common myeloid progenitor. Early
granulopoiesis requires the C/EBPα, PU. 1, RAR, CBF, and c-Myb transcription factors, and …

Glucose concentration may be an important factor in breast cancer cell proliferation, and the
prevalence of breast cancer is high in diabetic patients. Leptin may also be an important …

Stat3 is activated by phosphorylation on Tyr-705, which leads to dimer formation, nuclear
translocation, and regulation of gene expression. Serine phosphorylation of Stat3 by …

Protein kinase C (PKC) δ was the first new/novel PKC isoform to be identified by the
screening of mammalian cDNA libraries, based on the structural homology of its nucleotide …

Abstract Ingenol 3-angelate (I3A) is one of the active ingredients in Euphorbia peplus, which
has been used in traditional medicine. Here, we report the initial characterization of I3A as a …