Iron is an essential micronutrient for virtually all living cells. In infectious diseases, both
invading pathogens and mammalian cells including those of the immune system require iron …

▪ Abstract Hemoglobin degradation in intraerythrocytic malaria parasites is a vast process
that occurs in an acidic digestive vacuole. Proteases that participate in this catabolic …

Plasmodium falciparum resistance to artemisinin derivatives in southeast Asia threatens
malaria control and elimination activities worldwide. To monitor the spread of artemisinin …

The determinant of verapamil-reversible chloroquine resistance (CQR) in a Plasmodium
falciparum genetic cross maps to a 36 kb segment of chromosome 7. This segment harbors …

Quinoline-containing antimalarial drugs, such as chloroquine, quinine and mefloquine, are
mainstays of chemotherapy against malaria. The molecular basis of the action of these …

The artemisinin (ART)-based antimalarials have contributed significantly to reducing global
malaria deaths over the past decade, but we still do not know how they kill parasites. To gain …

The malaria parasite Plasmodium falciparum uses host erythrocyte hemoglobin as a major
nutrient source. We report the purification of P. falciparum digestive vacuoles and …

Proteases can be categorized based on their substrate specificities or mechanisms of
catalysis. Enzymes cleaving within a polypeptide chain are named endopeptidases, and …

Publisher Summary This chapter focuses on the most well characterized inhibitors—cystatin
C—and provide some information on its structure, biochemical properties, its role in normal …

Hemoglobin degradation is a metabolic process that is central to the growth and maturation
of the malaria parasite Plasmodium falciparum. Two aspartic proteases that initiate …