Escherichia coli as a host for metabolic engineering

S Pontrelli, TY Chiu, EI Lan, FYH Chen, P Chang… - Metabolic …, 2018 - Elsevier
Over the past century, Escherichia coli has become one of the best studied organisms on
earth. Features such as genetic tractability, favorable growth conditions, well characterized …

Biofuel production in Escherichia coli: the role of metabolic engineering and synthetic biology

JM Clomburg, R Gonzalez - Applied microbiology and biotechnology, 2010 - Springer
The microbial production of biofuels is a promising avenue for the development of viable
processes for the generation of fuels from sustainable resources. In order to become cost …

Improvement of Escherichia coli production strains by modification of the phosphoenolpyruvate:sugar phosphotransferase system

G Gosset - Microbial cell factories, 2005 - Springer
The application of metabolic engineering in Escherichia coli has resulted in the generation
of strains with the capacity to produce metabolites of commercial interest. Biotechnological …

CRISPRi allows optimal temporal control of N-acetylglucosamine bioproduction by a dynamic coordination of glucose and xylose metabolism in Bacillus subtilis

Y Wu, T Chen, Y Liu, X Lv, J Li, G Du… - Metabolic …, 2018 - Elsevier
Glucose and xylose are the two most abundant sugars in renewable lignocellulose sources;
however, typically they cannot be simultaneously utilized due to carbon catabolite …

Metabolic design of a platform Escherichia coli strain producing various chorismate derivatives

S Noda, T Shirai, S Oyama, A Kondo - Metabolic engineering, 2016 - Elsevier
A synthetic metabolic pathway suitable for the production of chorismate derivatives was
designed in Escherichia coli. An L-phenylalanine-overproducing E. coli strain was …

Rerouting fluxes of the central carbon metabolism and relieving mechanism-based inactivation of L-aspartate-α-decarboxylase for fermentative production of β …

B Li, B Zhang, P Wang, X Cai, YY Chen… - ACS Synthetic …, 2022 - ACS Publications
β-Alanine, with the amino group at the β-position, is an important platform chemical that has
been widely applied in pharmaceuticals and feed and food additives. However, the current …

Metabolic engineering of Escherichia coli for the production of fumaric acid

CW Song, DI Kim, S Choi, JW Jang… - Biotechnology and …, 2013 - Wiley Online Library
Fumaric acid is a naturally occurring organic acid that is an intermediate of the tricarboxylic
acid cycle. Fungal species belonging to Rhizopus have traditionally been employed for the …

Combinatorial modulation of galP and glk gene expression for improved alternative glucose utilization

J Lu, J Tang, Y Liu, X Zhu, T Zhang, X Zhang - Applied microbiology and …, 2012 - Springer
Phosphoenolpyruvate (PEP) is an important precursor for anaerobic production of succinate
and malate. Although inactivating PEP/carbohydrate phosphotransferase systems (PTS) …

Comparative genomics of the Komagataeibacter strains—Efficient bionanocellulose producers

M Ryngajłło, K Kubiak… - …, 2019 - Wiley Online Library
Komagataeibacter species are well‐recognized bionanocellulose (BNC) producers. This
bacterial genus, formerly assigned to Gluconacetobacter, is known for its phenotypic …

Challenges and opportunities for engineered Escherichia coli as a pivotal chassis toward versatile tyrosine-derived chemicals production

SSW Effendi, IS Ng - Biotechnology Advances, 2023 - Elsevier
Growing concerns over limited fossil resources and associated environmental problems are
motivating the development of sustainable processes for the production of high-volume fuels …