Mitochondrial uncoupling can be defined as a dissociation between mitochondrial
membrane potential generation and its use for mitochondria-dependent ATP synthesis …

Mitochondrial dysfunction is a crucial contributor to heart diseases. Alterations in energetic
metabolism affect crucial homeostatic processes, such asATP production, the generation of …

Background High-fat-diet (HFD) is associated with chronic low-grade inflammation. P2X7
purinergic receptors (P2X7R) are key regulators of inflammasome activation. The benefits of …

As one of the most serious complications of diabetes, diabetic cardiomyopathy (DCM)
imposes a huge burden on individuals and society, and represents a major public health …

A growing body of evidence suggests that exercise shows pleiotropic effects on the
maintenance of systemic homeostasis through mitochondria. Dysregulation of mitochondrial …

Septic cardiomyopathy is one of the most serious complications of sepsis or septic shock.
Basic and clinical research has studied the mechanism of cardiac dysfunction for more than …

We tested the hypothesis that creatine supplementation may potentiate exercise's protective
effects against doxorubicin-induced hepatotoxicity. Thirty-eight Swiss mice were randomly …

Abstract Type 2 diabetes (T2D) can cause severe cardiac complications at functional,
histologic and molecular levels. These pathological complications could be mediated by …

Background The effect of exercise on cardiac function/structure in type 2 diabetes mellitus
(T2DM) with or without diabetic cardiomyopathy (DCM) is not yet completely understood. To …

Recent trends suggest novel natural compounds as promising treatments for cardiovascular
disease. The authors examined how neopetroside A, a natural pyridine nucleoside …