Intercellular signaling molecules, known as morphogens, act at a long range in develo**
tissues to provide spatial information and control properties such as cell fate and tissue …

The Drosophila blastoderm and the vertebrate neural tube are archetypal examples of
morphogen-patterned tissues that create precise spatial patterns of different cell types. In …

Chromosomes in the eukaryotic nucleus are highly compacted. However, for many
functional processes, including transcription initiation, the pairwise motion of distal …

Spatiotemporal patterns of gene expression are fundamental to every developmental
program. The resulting macroscopic domains have been mainly characterized by their levels …

Morphogen gradients direct the spatial patterning of develo** embryos; however, the
mechanisms by which these gradients are interpreted remain elusive. Here we used lattice …

Early embryonic patterning events are strikingly precise, a fact that appears incompatible
with the stochastic gene expression observed across phyla. Using single-molecule mRNA …

Metazoan embryos develop from a single cell into three-dimensional structured organisms
while groups of genetically identical cells attain specialized identities. Cells of the …

How position-dependent cell fate acquisition occurs during embryogenesis is a central
question in developmental biology. To study this process, we developed a defined, high …

Summary Paused RNA polymerase (Pol II) is a pervasive feature of Drosophila embryos and
mammalian stem cells, but its role in development is uncertain. Here, we demonstrate that a …

Decapentaplegic (Dpp), the fly homolog of the secreted mammalian BMP2/4 signaling
molecules, is involved in almost all aspects of fly development. Dpp has critical functions at …