There has been a significant evolution in the definition and management of sepsis over the
last three decades. This is driven in part due to the advances made in our understanding of …

Highlights•CAR T cells are associated with unique side-effects.•Cytokine release syndrome
(CRS), immune effector cell-associated neurotoxicity syndrome (ICANS) and cytopenias are …

Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to
infection (1). Sepsis and septic shock are major healthcare problems, impacting millions of …

This is the first edition of this document for novel coronavirus, an adaption of WHO Clinical
management of severe acute respiratory infection when MERS-CoV infection is suspected …

Methods The original version of this document was developed in consultation with the
International Forum for Acute Care Trialists (InFACT), International Severe Acute Respiratory …

Background Coronavirus disease 2019 (COVID-19) is a respiratory tract infection caused by
a newly emergent coronavirus, that was first recognized in Wuhan, China, in December …

The guidance in this document is based on the above strategic priorities, and is intended for
clinicians involved in the care of patients with suspected or confirmed COVID-19. It is not …

The PRISMA statement is a reporting guideline designed to improve the completeness of
reporting of systematic reviews and meta-analyses. Authors have used this guideline …

Objective To provide an update to “Surviving Sepsis Campaign Guidelines for Management
of Sepsis and Septic Shock: 2012”. Design A consensus committee of 55 international …

This guideline is based on the above strategic priorities, and is intended for clinicians
involved in the care of patients with suspected or confirmed COVID-19. It is not meant to …