Connective tissue growth factor, also known as CCN2, is a cysteine-rich matricellular protein
involved in the control of biological processes, such as cell proliferation, differentiation …

Mutations of Lamin A/C gene (LMNA) cause laminopathies, a group of disorders associated
with a wide spectrum of clinically distinct phenotypes, affecting different tissues and organs …

Mutations in the lamin A/C gene (LMNA) cause dilated cardiomyopathy associated with
increased activity of ERK1/2 in the heart. We recently showed that ERK1/2 phosphorylates …

Mutations in the LaminA gene are a common cause of monogenic dilated cardiomyopathy.
Here we show that mice with a cardiomyocyte-specific Lmna deletion develop cardiac failure …

Connective tissue growth factor (CTGF), a multifunctional protein of the CCN family,
regulates cell proliferation, differentiation, adhesion, and a variety of other biological …

Severe cardiac remodeling leading to heart failure in individuals harboring pathogenic
LMNA variants, known as cardiolaminopathy, poses a significant clinical challenge …

Cardiac fibrosis is associated with non-ischemic dilated cardiomyopathy, increasing its
morbidity and mortality. Cardiac fibroblast is the keystone of fibrogenesis, being activated by …

Mutations in the gene for lamin A/C (LMNA) cause a diverse range of diseases known as
laminopathies. LMNA-related cardiomyopathy is a common inherited heart disease and is …

Fibrosis is defined by the excessive accumulation of extracellular matrix (ECM) and
constitutes a central pathophysiological process that underlies tissue dysfunction, across …

Cardiac fibrosis is referred to as an excessive accumulation of stromal cells and extracellular
matrix proteins in the myocardium. Progressive fibrosis causes stiffening of the cardiac …