The tumor suppressor p53 functions primarily as a transcription factor. Mutation of the TP53
gene alters its response pathway, and is central to the development of many cancers. The …

With artificial insemination (AI) and other precision dependent assisted reproductive
technologies (ART) being followed in large scale in human and animal reproduction …

We report that p73 is expressed in multiciliated cells (MCCs), is required for MCC
differentiation, and directly regulates transcriptional modulators of multiciliogenesis. Loss of …

Background It was believed earlier that spermatozoa have no traces of RNA because of loss
of most of the cytoplasm. Recent studies have revealed the presence of about 3000 different …

Background The importance of local breeds as genetic reservoirs of valuable genetic
variation is well established. Pig breeding in Central and South-Eastern Europe has a long …

Inbreeding depression is known to affect quantitative traits such as male fertility and sperm
quality, but the genetic basis for these associations is poorly understood. Most studies have …

The transcription factor p63 mediates distinct cellular responses, primarily regulating
epithelial and oocyte biology. In addition to the two amino terminal isoforms, TAp63 and …

Sperm cells are of unique elongated structure and function, the development of which is
tightly regulated by the existing proteins and the posttranslational modifications (PTM) of …

It is well accepted that expression of mutant p53 involves the gain of oncogenic-specific
activities accentuating the malignant phenotype. Depending on the specific cancer type …

Mutations in the TP53 tumour suppressor gene occur in half of all human cancers, indicating
its critical importance in inhibiting cancer development. Despite extensive studies, the …