Biomarkers of neurodegeneration and neuronal injury have the potential to improve
diagnostic accuracy, disease monitoring, prognosis, and measure treatment efficacy …

Neurofilaments (NFs) are unique among tissue-specific classes of intermediate filaments
(IFs) in being heteropolymers composed of four subunits (NF-L [neurofilament light]; NF-M …

Interest in neurofilaments has risen sharply in recent years with recognition of their potential
as biomarkers of brain injury or neurodegeneration in CSF and blood. This is in the context …

The advancing validation and exploitation of CSF and blood neurofilament light chain
protein as a biomarker of neuroaxonal damage has deeply changed the current diagnostic …

A majority of current disease-modifying therapeutic approaches for age-related
neurodegenerative diseases target their characteristic proteopathic lesions (α-synuclein …

Valid, responsive blood biomarkers specific to peripheral nerve damage would improve
management of peripheral nervous system (PNS) diseases. Neurofilament light chain (NfL) …

Human neurons engineered from induced pluripotent stem cells (iPSCs) through
neurogenin 2 (NGN2) overexpression are widely used to study neuronal differentiation …

Blood neurofilament light chain (NfL) is a marker of neuro-axonal injury showing promising
associations with outcomes of interest in several neurological conditions. Although initially …

Neurodegenerative diseases (NDs) are characterised by progressive dysfunction of
synapses, neurons, glial cells and their networks. Neurodegenerative diseases can be …

Many neurodegenerative disorders, including Parkinson's, Alzheimer's, and amyotrophic
lateral sclerosis, are well known to involve the accumulation of disease-specific proteins …