Background Extracellular matrix (ECM) is a dynamic and complex environment
characterized by biophysical, mechanical and biochemical properties specific for each …

All cells sense and integrate mechanical and biochemical cues from their environment to
orchestrate organismal development and maintain tissue homeostasis …

Spinal cord injury (SCI) is a refractory neurological disorder. Due to the complex
pathological processes, especially the secondary inflammatory cascade and the lack of …

Human-induced pluripotent stem cells (hiPSCs) have emerged as a promising in vitro model
system for studying neurodevelopment. However, current models remain limited in their …

Neural progenitor cell (NPC) culture within three-dimensional (3D) hydrogels is an attractive
strategy for expanding a therapeutically relevant number of stem cells. However, relatively …

Neural stem cells are multipotent cells with the ability to differentiate into neurons,
astrocytes, and oligodendrocytes. Lineage specification is strongly sensitive to the …

Cell state is often assayed through measurement of biochemical and biophysical markers.
Although biochemical markers have been widely used, intrinsic biophysical markers, such …

Tumor invasion and metastasis are strongly regulated by biophysical interactions between
tumor cells and the extracellular matrix (ECM). While the influence of ECM stiffness on cell …

Human pluripotent stem cells have emerged as a promising in vitro model system for
studying the brain. Two-dimensional and three-dimensional cell culture paradigms have …

The stiffness and nanotopographical characteristics of the extracellular matrix (ECM)
influence numerous developmental, physiological, and pathological processes in vivo …