The synthetic application of alkene ozonolysis is reviewed. Emphasis is placed on the scope
of potential transformations, traditional and emerging reaction protocols and technologies …

The cleavage of alkenes to the corresponding carbonyl products is a widely employed
method in organic synthesis, especially to introduce oxygen functionalities into molecules …

Natural products are embedded with structural motifs that inspire practitioners of synthetic
organic chemistry. The development of new synthetic methods and strategies for the …

Pre-equilibration of an interconverting set of isomeric allylic azides is coupled with an
intramolecular Schmidt reaction to afford substituted lactams stereoselectively. The effect of …

The preparation of tricyclic amines from acyclic precursors is described using a cascade of
tandem reactions involving condensation of an aldehyde with a primary amine, cyclization …

The total synthesis of the spiropiperidine alkaloid (−)‐perhydrohistrionicotoxin (perhydro‐
HTX) 2 has been accomplished on a gram scale by employing both conventional batch …

Tying the knot! The marriage of two-directional synthesis and tandem reactions allows
access to twelve skeletally diverse scaffolds in just fifteen reactions. Two-directional …

The enantioselective total synthesis of the bioactive marine natural products pinnaic acid
and halichlorine is reported in detail. Our total synthesis features the construction of the five …

The investigations of a synthetic route incorporating a NBS-promoted semipinacol
rearrangement to the 6-azaspiro [4.5] decane fragment within halichlorine (1) are presented …

A tandem one-pot reaction involving a condensation, then cyclization (N-alkylation),
followed by an azomethine ylide or nitrone dipolar cycloaddition allows a synthesis of …