Metals are common enzymatic cofactors, and their acquisition must be assured under the
various conditions encountered in the host. Although some strategies for acquisition of …

The aerobic catabolism of nicotinic acid (NA) is considered a model system for degradation
of N-heterocyclic aromatic compounds, some of which are major environmental pollutants; …

Publisher Summary This chapter presents an introduction to metallopeptidases and their
clans. Metallopeptidases are among the hydrolases in which the nucleophilic attack on a …

Many of the 181 families of peptidases contain homologues that are known to have functions
other than peptide bond hydrolysis. Distinguishing an active peptidase from a homologue …

The spread of antimicrobial resistance requires the development of novel strategies to
combat superbugs. Bacteriolytic enzymes (enzybiotics) that selectively eliminate pathogenic …

Staphylococcus aureus is a potent pathogen of humans exhibiting a broad disease range, in
part due to an extensive repertoire of secreted virulence factors, including proteases …

The foodborne pathogen Listeria monocytogenes employs a number of virulence
determinants including metalloproteases to infect hosts. Here for the first time, we identified …

Designing side chain substituents complementary to enzyme binding pockets is of great
importance in the construction of potent and selective phosphinic dipeptide inhibitors of …

The structure-property relationship is important in understanding molecular behaviors and
their best-fit areas of applications. 3-(4-hydroxyphenyl) prop-2-en-1-one 4-phenyl Schiff …

Hydroxy-2-pyridone (2, 5-DHP) is a central metabolic intermediate in catabolism of many
pyridine derivatives and has been suggested as a potential carcinogen. 2, 5-DHP is …