Every cell must satisfy basic requirements for nutrient sensing, utilization and recycling
through macromolecular breakdown to coordinate programmes for growth, repair and stress …

Abstract The Ser/Thr kinase mechanistic target of rapamycin (mTOR) is a central regulator of
cellular metabolism. As part of mTOR complex 1 (mTORC1), mTOR integrates signals such …

Enhancing the intracellular labile iron pool (LIP) represents a powerful, yet untapped
strategy for driving ferroptotic death of cancer cells. Here, we show that NRF2 maintains iron …

Repeated, episodic bouts of skeletal muscle contraction undertaken frequently as structured
exercise training are a potent stimulus for physiological adaptation in many organs …

The transcription factor TFEB is a master regulator of lysosomal biogenesis and autophagy.
The phosphorylation of TFEB by the mechanistic target of rapamycin complex 1 (mTORC1) …

Autophagy is a versatile degradation system for maintaining cellular homeostasis whereby
cytosolic materials are sequestered in a double-membrane autophagosome and …

Cells respond to mitochondrial poisons with rapid activation of the adenosine
monophosphate–activated protein kinase (AMPK), causing acute metabolic changes …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by protein
aggregation in the brain. Recent studies have revealed the critical role of microglia in AD …

Autophagy is an evolutionarily conserved, lysosome-dependent catabolic process whereby
cytoplasmic components, including damaged organelles, protein aggregates and lipid …

The evolution of AMPK and its homologs enabled exquisite responsivity and control of
cellular energetic homeostasis. Recent work has been critical in establishing the …