Glioblastoma is an aggressive and inevitably recurrent primary intra-axial brain tumor with a
dismal prognosis. The current mainstay of treatment involves maximally safe surgical …

Despite decades of intense research, the complex biology of glioblastoma (GBM) is not
completely understood. Progression-free survival and overall survival have remained …

Background The prediction of clinical behavior, response to therapy, and outcome of
infiltrative glioma is challenging. On the basis of previous studies of tumor biology, we …

Currently, gliomas are diagnosed by neuroimaging, and refined diagnosis requires
resection or biopsy to obtain tumour tissue for histopathological classification and grading …

Background Mutations of the isocitrate dehydrogenase 1 and 2 gene (IDH1/2) were initially
thought to enhance cancer cell survival and proliferation by promoting the Warburg effect …

Gliomas are the most malignant and aggressive primary brain tumor in adults. Despite
concerted efforts to improve therapies, their prognosis remains very poor. Isocitrate …

Isocitrate Dehydrogenase (IDH)1/2 Mutations as Prognostic Ma... : Medicine Isocitrate
Dehydrogenase (IDH)1/2 Mutations as Prognostic Markers in Patients With Glioblastomas …

Glioblastoma multiforme (GBM), or grade IV astrocytoma, is the most common type of
primary brain tumor. It has a devastating prognosis with a 2-year-overall survival rate of only …

Malignant tumors of the central nervous system (CNS) are among cancers with the poorest
prognosis, indicated by their association with tumors of high-level morbidity and mortality …

Despite intensive research, malignant brain tumors are among the most difficult to treat due
to high resistance to conventional therapeutic approaches. High-grade malignant gliomas …