Bi-aryl meta-pyrimidine inhibitors of kinases

G Noronha, CC Mak, J Cao, J Renick… - US Patent …, 2010 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
38006192&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

2, 4-Pyrimidinediamine compounds and their uses

R Singh, A Argade, D Payan, S Molineaux… - US Patent …, 2008 - Google Patents
Abstract The present invention provides 2, 4-pyrimidinediamine compounds that inhibit the
IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators …

5-Fluoro-4N-phenyl-4-pyrimidineamine compounds

R Singh, A Argade, D Payan, S Molineaux… - US Patent …, 2009 - Google Patents
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Prodrugs of 2, 4-pyrimidinediamine compounds and their uses

S Bhamidipati, R Singh, VJ Stella, T Sun - US Patent 7,449,458, 2008 - Google Patents
The present disclosure provides prodrugs of biologically active 2.4-pyrimidinediamine
compounds of structural for mula shown below, compositions comprising these com pounds …

EGFR inhibitors and methods of treating disorders

NS Gray, P Janne, MJ Eck, W Zhou - US Patent 9,908,884, 2018 - Google Patents
The present invention relates to novel pyrimidine, pyrrolo pyrimidine, pyrrolo-pyridine,
pyridine, purine and triazine compounds which are able to modulate epidermal growth factor …

JAK kinase inhibitors and their uses

B Wong - US Patent App. 11/416,652, 2006 - Google Patents
2. BACKGROUND 0002 Protein kinases constitute a large family of struc turally related
enzymes that are responsible for the control of a variety of signal transduction processes …

Methods of treating or preventing autoimmune diseases with 2, 4-pyrimidinediamine compounds

R Singh, A Argade, H Li, S Bhamidipati… - US Patent …, 2012 - Google Patents
2005-01-14 Assigned to RIGEL PHARMACEUTICALS, INC. reassignment RIGEL
PHARMACEUTICALS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …

Compositions and methods for inhibition of the jak pathway

A Argade, A Sran, D Carroll, J Clough… - US Patent App. 11 …, 2007 - Google Patents
2007-04-05 Assigned to RIGEL PHARMACEUTICALS, INC. reassignment RIGEL
PHARMACEUTICALS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …

2, 4-pyrimidinediamine compounds and their uses

R Singh, A Argade, D Payan, S Molineaux… - US Patent …, 2009 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
32996332&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

Compositions and methods for inhibition of the JAK pathway

H Li, V Taylor, S Bhamidipati, J Ramphal, K Tso… - US Patent …, 2010 - Google Patents
The present invention relates to compounds, prodrugs, and methods of using these
compounds and prodrugs thereof in the treatment of conditions in which modulation of the …