Many drugs, or their antecedents, were discovered through observation of their effects on
normal or disease physiology. For the past generation, this phenotypic drug discovery …

Epigenetic Therapies for Cancer | New England Journal of Medicine Skip to main content The
New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …

Respiratory failure is the leading cause of death in patients with severe SARS-CoV-2
infection,, but the host response at the lung tissue level is poorly understood. Here we …

Clear cell renal carcinoma (ccRCC) is a heterogeneous disease with a variable post-
surgical course. To assemble a comprehensive ccRCC tumor microenvironment (TME) …

The clinical relevance of comprehensive molecular analysis in rare cancers is not
established. We analyzed the molecular profiles and clinical outcomes of 1,310 patients …

Purpose: Cancer-associated fibroblasts (CAF) have been implicated as potential mediators
of checkpoint immunotherapy response. However, the extensive heterogeneity of these cells …

Multiple endocrine neoplasia type 1 (MEN1), a rare tumor syndrome that is inherited in an
autosomal dominant pattern, is continuing to raise great interest for endocrinology …

Bulk-tissue DNA methylomes represent an average over many different cell types,
hampering our understanding of cell-type-specific contributions to disease development. As …

Neuroendocrine neoplasms (NENs) comprise well-differentiated neuroendocrine tumors
(NETs) and poorly differentiated neuroendocrine carcinomas (NECs). Treatment options for …

When compared to other malignancies, the tumor microenvironment (TME) of primary and
castration-resistant prostate cancer (CRPC) is relatively devoid of immune infiltrates. While …