Our sleep timing preference, or chronotype, is a manifestation of our internal biological
clock. Variation in chronotype has been linked to sleep disorders, cognitive and physical …

The Nijmegen Biomedical Study (NBS) is a population-based study that was initiated (by LK
and AV) in 2000 in the municipality of Nijmegen (150 000 inhabitants) in the eastern part of …

Investigations of pathophysiological mechanisms implicated in vulnerability to depression
have been negatively impacted by the significant heterogeneity characteristic of psychiatric …

Despite decades of research and advancements in diagnostics and treatment, tuberculosis
remains a major public health concern. New computational methods are needed to …

Motivation Genotype imputation is essential for genome-wide association studies (GWAS) to
retrieve information of untyped variants and facilitate comparability across studies. However …

Complex shotgun proteomics peptide profiles obtained in quantitative differential protein
expression studies, such as in biomarker discovery, may be affected by multiple …

Motivation Complex neuropsychiatric conditions including autism spectrum disorders are
among the most heritable neurodevelopmental disorders with distinct profiles of …

This paper reports on the development of a self-sustaining and community-responsive
platform that streamlines the wealth of available open Bioinformatics resources to accelerate …

The highly competitive environment of post-genomics biomedical research is pushing
towards the production of highly qualified results and their utilization in clinical practice. Due …

In this thesis we aimed to unravel novel mechanisms underlying asthma and allergy, and to
translate this to clinical application. The focus is on 2 genes: Interleukin 33 (IL33) and …