Ebselen and analogues: Pharmacological properties and synthetic strategies for their preparation

C Santi, C Scimmi, L Sancineto - Molecules, 2021 - mdpi.com
Ebselen is the leader of selenorganic compounds, and starting from its identification as
mimetic of the key antioxidant enzyme glutathione peroxidase, several papers have …

Synthesis of organoselenium compounds with elemental selenium

YT Ma, MC Liu, YB Zhou, HY Wu - Advanced Synthesis & …, 2021 - Wiley Online Library
In the recent decade, growing efforts have been devoted to employing elemental selenium
as a selenium source in organic synthesis. In contrast to unstable, smelly, and toxic previous …

Rational design and action mechanisms of chemically innovative organoselenium in cancer therapy

Z Chen, H Lai, L Hou, T Chen - Chemical Communications, 2020 - pubs.rsc.org
Organo-seleno compounds (org-Se) have been widely used in antitumor, antiviral, and
antiinflammatory therapy; antioxidation and other biological fields. As such, they have made …

Recent developments in the synthesis of biologically relevant selenium-containing scaffolds

B Banerjee, M Koketsu - Coordination Chemistry Reviews, 2017 - Elsevier
Recent, many methods have been reported for the synthesis of selenium-containing
bioactive scaffolds because of their interesting reactivity and potential pharmaceutical …

Small-Molecule Ebselen Binds to YTHDF Proteins Interfering with the Recognition of N6-Methyladenosine-Modified RNAs

M Micaelli, A Dalle Vedove, L Cerofolini… - ACS Pharmacology & …, 2022 - ACS Publications
YTHDF proteins bind the N 6-methyladenosine (m6A)-modified mRNAs, influencing their
processing, stability, and translation. Therefore, the members of this protein family play …

Transition-metal-free synthesis of unsymmetrical diaryl chalcogenides from arenes and diaryl dichalcogenides

CD Prasad, SJ Balkrishna, A Kumar… - The Journal of …, 2013 - ACS Publications
A transition-metal-free synthetic method has been developed for the synthesis of
unsymmetrical diaryl chalcogenides (S, Se, and Te) from diaryl dichalcogenides and arenes …

Recent advances in organic synthesis applying elemental selenium

T Guo, Z Li, L Bi, L Fan, P Zhang - Tetrahedron, 2022 - Elsevier
The synthesis of organoselenium compounds through C–Se bond-forming has attracted
immense attention due to their biological values and extensive pharmaceutical applications …

Photoinduced Construction of Thieno[3,4-c]quinolin-4(5H)-ones/Selenopheno[3,4-c]quinolin-4(5H)-ones Using Diphenyl Disulfide or Diphenyl Diselenide as Sulfur …

SY Tian, JJ Ai, JH Han, W Rao, SS Shen… - The Journal of …, 2022 - ACS Publications
A photocatalytic synthesis of thieno [3, 4-c] quinolin-4 (5 H)-ones/selenopheno [3, 4-c]
quinolin-4 (5 H)-ones using diphenyl disulfide or diphenyl diselenide as sulfur or selenium …

KOtBu Mediated Synthesis of Phenanthridinones and Dibenzoazepinones

BS Bhakuni, A Kumar, SJ Balkrishna, JA Sheikh… - Organic …, 2012 - ACS Publications
Synthesis of substituted phenanthridinones and dibenzoazepinones has been realized from
2-halo-benzamides in the presence of potassium tert-butoxide and a catalytic amount of 1 …

Multifunctional Antioxidants: Regenerable Radical‐Trap** and Hydroperoxide‐Decomposing Ebselenols

S Kumar, J Yan, J Poon, VP Singh, X Lu… - Angewandte Chemie …, 2016 - Wiley Online Library
Regenerable, multifunctional ebselenol antioxidants were prepared that could quench
peroxyl radicals more efficiently than α‐tocopherol. These compounds act as better mimics …