Signal transduction: From the atomic age to the post-genomic era
We have come a long way in the 55 years since Edmond Fischer and the late Edwin Krebs
discovered that the activity of glycogen phosphorylase is regulated by reversible protein …
discovered that the activity of glycogen phosphorylase is regulated by reversible protein …
Coincident signals from GPCRs and receptor tyrosine kinases are uniquely transduced by PI3Kβ in myeloid cells
DM Houslay, KE Anderson, T Chessa, S Kulkarni… - Science …, 2016 - science.org
Class I phosphoinositide 3-kinases (PI3Ks) catalyze production of the lipid messenger
phosphatidylinositol 3, 4, 5-trisphosphate (PIP3), which plays a central role in a complex …
phosphatidylinositol 3, 4, 5-trisphosphate (PIP3), which plays a central role in a complex …
Combined inhibition of PI3Kβ and PI3Kγ reduces fat mass by enhancing α-MSH–dependent sympathetic drive
A Perino, M Beretta, A Kilić, A Ghigo, D Carnevale… - Science …, 2014 - science.org
Obesity is defined as an abnormal increase in white adipose tissue and has become a major
medical burden worldwide. Signals from the brain control not only appetite but also energy …
medical burden worldwide. Signals from the brain control not only appetite but also energy …
[HTML][HTML] PI3King the right partner: unique interactions and signaling by p110β
HA Dbouk - Postdoc journal: a journal of postdoctoral research and …, 2015 - ncbi.nlm.nih.gov
Abstract Phosphoinositide 3-kinases (PI3Ks) are central regulators of cellular responses to
extracellular stimuli, and are involved in growth, proliferation, migration, and metabolism …
extracellular stimuli, and are involved in growth, proliferation, migration, and metabolism …
Signaling Mechanisms on Membrane Surfaces: Studies of Membrane-Bound Master Kinases
TC Buckles - 2019 - search.proquest.com
The leading edge pseudopod of polarized chemotaxing eukaryotic cells is a membrane
associated signaling platform integral to movement, gene expression, growth and …
associated signaling platform integral to movement, gene expression, growth and …