Understanding respiratory microbiome–immune system interactions in health and disease

SK Di Simone, I Rudloff, CA Nold-Petry… - Science translational …, 2023 - science.org
Interactions between the develo** microbiome and maturing immune system in early life
are critical for establishment of a homeostasis beneficial to both host and commensals. The …

Unravelling the respiratory health path across the lifespan for survivors of preterm birth

SJ Simpson, C Du Berry, DJ Evans… - The Lancet …, 2024 - thelancet.com
Many survivors of preterm birth will have abnormal lung development, reduced peak lung
function and, potentially, an increased rate of physiological lung function decline, each of …

Anakinra Pilot–a clinical trial to demonstrate safety, feasibility and pharmacokinetics of interleukin 1 receptor antagonist in preterm infants

EA Green, D Metz, R Galinsky, R Atkinson… - Frontiers in …, 2022 - frontiersin.org
Background Bronchopulmonary dysplasia (BPD), its complication pulmonary hypertension
(BPD-PH) and preterm brain and gut injury lead to significant morbidity and mortality in …

Bronchopulmonary dysplasia–associated pulmonary hypertension: An updated review

A El-Saie, NP Varghese, MK Webb, N Villafranco… - Seminars in …, 2023 - Elsevier
Bronchopulmonary dysplasia (BPD) is the leading cause of chronic lung disease in infants
and the commonest complication of prematurity. Advances in respiratory and overall …

The role of the interleukin-1 family in complications of prematurity

EA Green, SP Garrick, B Peterson, PJ Berger… - International Journal of …, 2023 - mdpi.com
Preterm birth is a major contributor to neonatal morbidity and mortality. Complications of
prematurity such as bronchopulmonary dysplasia (BPD, affecting the lung), pulmonary …

Development of a peripheral blood transcriptomic gene signature to predict bronchopulmonary dysplasia

A Moreira, M Tovar, AM Smith… - … of Physiology-Lung …, 2023 - journals.physiology.org
Bronchopulmonary dysplasia (BPD) is the most common lung disease of extreme
prematurity, yet mechanisms that associate with or identify neonates with increased …

[HTML][HTML] Activated eosinophils in early life impair lung development and promote long-term lung damage

AL Raftery, CA O'Brien, A Shad… - Mucosal …, 2024 - Elsevier
HIGHLIGHTS•Activated eosinophils have a detrimental long-term impact on the develo**
lung.•Activated eosinophils in early life negatively impact lung structure and …

[HTML][HTML] Fetal growth restriction and neonatal-pediatric lung diseases: Vascular mechanistic links and therapeutic directions

A Sehgal, T Dassios, MF Nold, CA Nold-Petry… - Paediatric respiratory …, 2022 - Elsevier
Bronchopulmonary dysplasia (BPD) is the most common respiratory sequela of prematurity,
and infants born with fetal growth restriction (FGR) are disproportionately represented in …

Human BioMolecular Atlas Program (HuBMAP): 3D Human Reference Atlas Construction and Usage

K Börner, PD Blood, JC Silverstein, M Ruffalo… - …, 2024 - pmc.ncbi.nlm.nih.gov
The Human BioMolecular Atlas Program (HuBMAP) aims to construct a reference 3D
structural, cellular, and molecular atlas of the healthy adult human body. The HuBMAP Data …

Unlocking the potential for microbiome‐based therapeutics to address the sustainable development goal of good health and wellbeing

EL Gulliver, SK Di Simone… - Microbial …, 2024 - Wiley Online Library
Recent years have witnessed major advances and an ever‐growing list of healthcare
applications for microbiome‐based therapeutics. However, these advances have …