Airway inflammation in COPD: progress to precision medicine

C Brightling, N Greening - European Respiratory Journal, 2019‏ - publications.ersnet.org
Chronic obstructive pulmonary disease (COPD) is a significant cause of morbidity and
mortality worldwide, and its prevalence is increasing. Airway inflammation is a consistent …

Role of IL‐25, IL‐33, and TSLP in triggering united airway diseases toward type 2 inflammation

H Hong, S Liao, F Chen, Q Yang, DY Wang - Allergy, 2020‏ - Wiley Online Library
Under the concept of" united airway diseases," the airway is a single organ wherein upper
and lower airway diseases are commonly comorbid. The upper and lower airways are lined …

Definition and nomenclature of chronic obstructive pulmonary disease: time for its revision

B Celli, L Fabbri, G Criner, FJ Martinez… - American journal of …, 2022‏ - atsjournals.org
Attempts to define concepts and things date back to the time of Aristotle, around 2,400 years
ago, when he proposed that a definition should state the essential nature or being of …

Efficacy and safety of itepekimab in patients with moderate-to-severe asthma

ME Wechsler, MK Ruddy, ID Pavord… - New England journal …, 2021‏ - Mass Medical Soc
Abstract Background Monoclonal antibodies targeting IgE, interleukin-4 and-13, and
interleukin-5 are effective in treating severe type 2 asthma, but new targets are needed …

Precision medicine and phenotypes, endotypes, genotypes, regiotypes, and theratypes of allergic diseases

I Agache, CA Akdis - The Journal of clinical investigation, 2019‏ - jci.org
A rapidly develo** paradigm for modern health care is a proactive and individualized
response to patients' symptoms, combining precision diagnosis and personalized treatment …

The asthma–COPD overlap syndrome

DS Postma, KF Rabe - New England Journal of Medicine, 2015‏ - Mass Medical Soc
The Asthma–COPD Overlap Syndrome | New England Journal of Medicine Skip to main content
The New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …

Airway epithelial barrier dysfunction in chronic obstructive pulmonary disease: role of cigarette smoke exposure

M Aghapour, P Raee, SJ Moghaddam… - American journal of …, 2018‏ - atsjournals.org
The epithelial lining of the airway forms the first barrier against environmental insults, such
as inhaled cigarette smoke, which is the primary risk factor for the development of chronic …

[HTML][HTML] Chronic obstructive pulmonary disease: epidemiology, biomarkers, and paving the way to lung cancer

K Szalontai, N Gémes, J Furák, T Varga… - Journal of clinical …, 2021‏ - mdpi.com
Chronic obstructive pulmonary disease (COPD), the frequently fatal pathology of the
respiratory tract, accounts for half a billion cases globally. COPD manifests via chronic …

What is asthma− COPD overlap syndrome? Towards a consensus definition from a round table discussion

DD Sin, M Miravitlles, DM Mannino… - European …, 2016‏ - publications.ersnet.org
Patients with asthma–chronic obstructive pulmonary disease overlap syndrome (ACOS)
have been largely excluded from pivotal therapeutic trials and, as a result, its treatment …

Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine

CA Brandsma, M Van den Berge… - The Journal of …, 2020‏ - Wiley Online Library
Chronic obstructive pulmonary disease (COPD) is a devastating lung disease with a high
personal and societal burden. Exposure to toxic particles and gases, including cigarette …