Metastasis is the spread of cancer cells from the primary tumour to distant sites and organs
throughout the body. It is the primary cause of cancer morbidity and mortality, and is …

Human tumors often trigger a hypercoagulable state that promotes hemostatic
complications, including venous thromboembolism. The recent application of systems …

Radiation therapy (RT) provides therapeutic benefits for patients with glioblastoma (GBM),
but inevitably induces poorly understood global changes in GBM and its microenvironment …

There is a strong relationship between tissue factor (TF) and cancer. Many cancer cells
express high levels of both full-length TF and alternatively spliced (as) TF. TF expression in …

Assessment of cell free DNA (cfDNA) and RNA (cfRNA), circulating tumor cells (CTC) and
extracellular vesicles (EV) in blood or other bodily fluids can enable early cancer detection …

Background Transmembrane serine protease 4 (TMPRSS4) is a cell surface–anchored
serine protease. Elevated expression of TMPRSS4 correlates with poor prognosis in …

Epithelial–mesenchymal transitions (EMTs) generate hybrid phenotypes with an enhanced
ability to adapt to diverse microenvironments encountered during the metastatic spread …

Purpose: Fibroblasts expressing the orphan chemokine CXCL14 have been previously
shown to associate with poor breast cancer prognosis and promote cancer growth. This …

Tumor cells demonstrate substantial plasticity in their genotypic and phenotypic
characteristics. Epithelial-mesenchymal plasticity (EMP) can be characterized into dynamic …

Abstract Epithelial-to-Mesenchymal Transition (EMT) is a complex process that supports the
migratory capacity of epithelial tumor cells and is thought to play a crucial role in promoting …