Arsenic toxicity: molecular targets and therapeutic agents

VM Nurchi, A Buha Djordjevic, G Crisponi, J Alexander… - Biomolecules, 2020 - mdpi.com
High arsenic (As) levels in food and drinking water, or under some occupational conditions,
can precipitate chronic toxicity and in some cases cancer. Millions of people are exposed to …

Arsenic-induced neurotoxicity: a mechanistic appraisal

C Garza-Lombó, A Pappa, MI Panayiotidis… - JBIC Journal of …, 2019 - Springer
Arsenic is a metalloid found in groundwater as a byproduct of soil/rock erosion and industrial
and agricultural processes. This xenobiotic elicits its toxicity through different mechanisms …

Arsenite induces ferroptosis in the neuronal cells via activation of ferritinophagy

J **ao, S Zhang, B Tu, X Jiang, S Cheng, Q Tang… - Food and Chemical …, 2021 - Elsevier
Ferroptosis is a novel form of cell death that involves in the pathophysiological process of
diverse brain diseases. However, how arsenite induces ferroptosis in the neuronal cells …

[HTML][HTML] Prenatal and childhood arsenic exposure through drinking water and food and cognitive abilities at 10 years of age: A prospective cohort study

M Vahter, H Skröder, SM Rahman, M Levi… - Environment …, 2020 - Elsevier
Background Our studies of children in a rural Bangladeshi area, with varying concentrations
of arsenic in well-water, indicated modest impact on child verbal cognitive function at 5 years …

Arsenic toxicity: sources, pathophysiology and mechanism

SY Ganie, D Javaid, YA Hajam… - Toxicology Research, 2024 - academic.oup.com
Background Arsenic is a naturally occurring element that poses a significant threat to human
health due to its widespread presence in the environment, affecting millions worldwide …

Toxic metal (loid)-based pollutants and their possible role in autism spectrum disorder

G Bjørklund, AV Skalny, MM Rahman, M Dadar… - Environmental …, 2018 - Elsevier
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits
in social interaction, verbal and non-verbal communication, and stereotypic behaviors. Many …

Chronic dietary exposure to arsenic at environmentally relevant concentrations impairs cognitive performance in adult zebrafish (Danio rerio) via oxidative stress and …

M Rachamalla, A Salahinejad, M Khan… - Science of The Total …, 2023 - Elsevier
The current study was designed to evaluate the effects of chronic dietary arsenic exposure
on the cognitive performance of adult zebrafish and uncover probable pathways by which …

Proteomic study on the mechanism of arsenic neurotoxicity in the rat cerebral cortex and the protective mechanism of dictyophora polysaccharides against arsenic …

X Zhang, H Yang, Y Wang, J Zhang… - ACS Chemical …, 2023 - ACS Publications
Arsenic (As) is a toxic element, and long-term exposure to As can cause neurotoxicity. The
bioactive natural compound Dictyophora polysaccharide (DIP) from edible plants has been …

Mechanisms of metal-induced mitochondrial dysfunction in neurological disorders

H Cheng, B Yang, T Ke, S Li, X Yang, M Aschner… - Toxics, 2021 - mdpi.com
Metals are actively involved in multiple catalytic physiological activities. However, metal
overload may result in neurotoxicity as it increases formation of reactive oxygen species …

Exposure to low doses of inorganic arsenic induces transgenerational changes on behavioral and epigenetic markers in zebrafish (Danio rerio)

S Valles, J Hernández-Sánchez, VR Dipp… - Toxicology and Applied …, 2020 - Elsevier
The ability of environmental pollutants to alter the epigenome with resultant development of
behavioral alterations has received more attention in recent years. These alterations can be …