Cell-associated proteoglycans provide highly complex and sophisticated systems to control
interactions of extracellular cell matrix components and soluble ligands with the cell surface …

In hormone-dependent breast cancer, estrogen receptors are the principal signaling
molecules that regulate several cell functions either by the genomic pathway acting directly …

Heparan sulfate proteoglycans (HSPGs) are an integral and dynamic part of normal tissue
architecture at the cell surface and within the extracellular matrix. The modification of HSPGs …

Glycosylation is a common and widespread post-translational modification that affects a
large majority of proteins. Of these, a small minority, about 20, are specifically modified by …

Hepatocyte growth factor plays multiple roles in cancer, by acting as a motility and invasion
stimulating factor, promoting metastasis and tumour growth. Furthermore, it acts as a …

Importance of the field: Sulf-1 and Sulf-2 are sulfatases that edit the sulfation status of
heparan sulfate proteoglycans (HSPGs) on the outside of cells and regulate a number of …

Background Tobacco use remains the leading preventable cause of death in the US. The
risk of dying from smoking-related diseases remains elevated for former smokers years after …

Background Heparin/heparan sulfate (HS) proteoglycans are found in the extracellular
matrix (ECM) and on the cell surface. A considerable body of evidence has established that …

SULF1 has been implicated in a number of malignancies. The function of SULF1 in gastric
cancer is disputed. The objective of this study was to examine the role and underlying …

It has been shown that the heparin‐degrading endosulfatase, sulfatase 1 (SULF1), functions
as a liver tumor suppressor, but the role of the related sulfatase, sulfatase 2 (SULF2), in liver …