Advances in metabolic engineering of Corynebacterium glutamicum to produce high-value active ingredients for food, feed, human health, and well-being

S Wolf, J Becker, Y Tsuge, H Kawaguchi… - Essays in …, 2021 - portlandpress.com
The soil microbe Corynebacterium glutamicum is a leading workhorse in industrial
biotechnology and has become famous for its power to synthetise amino acids and a range …

[HTML][HTML] Recent trends in microbial flavour Compounds: A review on Chemistry, synthesis mechanism and their application in food

DK Verma, STG Al-Sahlany, AK Niamah… - Saudi Journal of …, 2022 - Elsevier
Aroma and flavour represent the key components of food that improves the organoleptic
characteristics of food and enhances the acceptability of food to consumers. Commercial …

High-throughput screening for efficient microbial biotechnology

A Sarnaik, A Liu, D Nielsen, AM Varman - Current opinion in biotechnology, 2020 - Elsevier
Highlights•High-throughput screening (HTS) facilitates selection of the best performing
strain.•Biosensor-enabled HTS obviates the need for sophisticated analytical …

Fermentative High-Level Production of 5-Hydroxyvaleric Acid by Metabolically Engineered Corynebacterium glutamicum

YJ Sohn, M Kang, KA Baritugo, J Son… - ACS Sustainable …, 2021 - ACS Publications
We report metabolic engineering of Corynebacterium glutamicum (C. glutamicum) for high-
level production of 5-hydroxyvaleric acid (5-HV), an important C5 platform chemical covering …

[HTML][HTML] Prospective bacterial and fungal sources of hyaluronic acid: A review

EV Shikina, RA Kovalevsky, AI Shirkovskaya… - Computational and …, 2022 - Elsevier
The unique biological and rheological properties make hyaluronic acid a sought-after
material for medicine and cosmetology. Due to very high purity requirements for hyaluronic …

[HTML][HTML] Progress on the Synthesis Pathways and Pharmacological Effects of Naturally Occurring Pyrazines

X Liu, W Quan - Molecules, 2024 - mdpi.com
As one of the most essential types of heterocyclic compounds, pyrazines have a
characteristic smell and taste and have a wide range of commercial applications, especially …

Sustainable production of 2,3,5,6-Tetramethylpyrazine at high titer in engineered Corynebacterium glutamicum

A Srinivasan, K Chen-**ao, D Banerjee… - Journal of Industrial …, 2024 - academic.oup.com
The industrial amino acid production workhorse, Corynebacterium glutamicum naturally
produces low levels of 2, 3, 5, 6-tetramethylpyrazine (TMP), a valuable flavor, fragrance, and …

Genomics Characterization of an Engineered Corynebacterium glutamicum in Bioreactor Cultivation Under Ionic Liquid Stress

D Banerjee, T Eng, Y Sasaki, A Srinivasan… - … in Bioengineering and …, 2021 - frontiersin.org
Corynebacterium glutamicum is an ideal microbial chassis for production of valuable
bioproducts including amino acids and next generation biofuels. Here we resequence …

Sustainable production of 2,3,5,6-Tetramethylpyrazine at high titer in engineered Corynebacterium glutamicum using statistical design of experiments

A Srinivasan, K Chen-**ao, D Banerjee, A Oka… - bioRxiv, 2023 - biorxiv.org
Background The industrial amino acid production workhorse, Corynebacterium glutamicum
naturally produces low levels of 2, 3, 5, 6-tetramethylpyrazine (TMP), a valuable flavor …

Impact of Tlr5 Overexpression on Gut Microbiota and Metabolites: Insights into Salmonella Infection Outcomes

C Lei, X Zhao, Y Wang, L Jiang, L Zhang… - Available at SSRN … - papers.ssrn.com
Background: The gut microbiome and the host immune system work together to maintain
intestinal health and protect against infections. Toll-like receptor 5 (TLR5) recognizes …