Erythropoiesis is a complex multistep process encompassing the differentiation of
hemopoietic stem cells to mature erythrocytes. The steps involved in this complex …

Preneoplastic lesions carry many of the antigenic targets found in cancer cells but often
exhibit prolonged dormancy. Understanding how the host response to premalignancy is …

Abstract Apoptosis through Fas/Fas ligand (FasL) is an important regulator of immune
system homeostasis but its role in bone homeostasis is elusive. We systematically analyzed …

Normal erythropoiesis critically depends on the balance between the renewal of precursor
cells and their differentiation. If the renewal phase is shortened, the decrease in the …

Potential applications of neural stem cells (NSCs) for transplantation requires understanding
myosin heavy chain (MHC) expression and the ability of T cells and natural killer (NK) cells …

During the last decade, the concerted effort of numerous scientific groups has expanded our
understanding of the finely tuned network present within bone marrow for the regulation of …

ABSTRACT CD40 is a member of the TNFR family and upon interaction with its cognate
ligand (CD40L), induces diverse biologic responses related to cell survival/growth. As …

Background Chronic myeloproliferative disorders (MPDs) are clonal haematopoietic stem
cell malignancies characterised by an accumulation of mature myeloid cells in bone marrow …

While the relationship between cellular apoptosis and proliferation rates in COVID patients
remains underexplored in existing literature, various viruses are known to impact these …

Genetic loss of surface Fas antigen expression leads to reduced apoptosis of myeloid and
lymphoid progenitor cells, and a propensity to develop autoimmunity and myeloid leukemia …