The transition from normal to chronic pain is believed to involve alterations in several brain
areas that participate in the perception of pain. These plastic changes are then responsible …

Chronic pain is not simply a temporal continuum of acute pain. Studies on functional
plasticity in neural circuits of pain have provided mechanistic insights and linked various …

Pain is an integrative phenomenon that results from dynamic interactions between sensory
and contextual (ie, cognitive, emotional, and motivational) processes. In the brain the …

Pain and stress share significant conceptual and physiological overlaps. Both phenomena
challenge the body's homeostasis and necessitate decision-making to help animals adapt to …

Traditionally, studies of how pain and attention modulate one another involved explicit
cognitive-state manipulations. However, emerging evidence suggests that spontaneous …

Chronic pain conditions are associated with abnormalities in brain structure and function.
Moreover, some studies indicate that brain activity related to the subjective perception of …

Chronic pain is associated with neuronal plasticity. Here we use resting-state functional
magnetic resonance imaging to investigate functional changes in patients suffering from …

Several theoretical frameworks have been proposed to explain the physiological basis of
pain, although none yet completely accounts for all aspects of pain perception. Here, we …

Information processing during human cognitive and emotional operations is thought to
involve the dynamic interplay of several large-scale neural networks, including the fronto …

Patients with fibromyalgia (FM) show characteristically enhanced unpleasantness to painful
and nonpainful sensations accompanied by altered neural responses. The diagnostic …