[HTML][HTML] Towards the sustainable discovery and development of new antibiotics
An ever-increasing demand for novel antimicrobials to treat life-threatening infections
caused by the global spread of multidrug-resistant bacterial pathogens stands in stark …
caused by the global spread of multidrug-resistant bacterial pathogens stands in stark …
Glycomimetics for the inhibition and modulation of lectins
Carbohydrates are essential mediators of many processes in health and disease. They
regulate self-/non-self-discrimination, are key elements of cellular communication, cancer …
regulate self-/non-self-discrimination, are key elements of cellular communication, cancer …
A series of MOF/Ce-based nanozymes with dual enzyme-like activity disrupting biofilms and hindering recolonization of bacteria
Notorious bacterial biofilms are becoming severe threats to public health worldwide. As the
important component in biofilm extracellular polymeric substances (EPS), extracellular DNA …
important component in biofilm extracellular polymeric substances (EPS), extracellular DNA …
Advancements in antimicrobial nanoscale materials and self-assembling systems
Antimicrobial resistance is directly responsible for more deaths per year than either
HIV/AIDS or malaria and is predicted to incur a cumulative societal financial burden of at …
HIV/AIDS or malaria and is predicted to incur a cumulative societal financial burden of at …
The Pseudomonas aeruginosa lectin LecB binds to the exopolysaccharide Psl and stabilizes the biofilm matrix
D Passos da Silva, ML Matwichuk… - Nature …, 2019 - nature.com
Pseudomonas aeruginosa biofilms are composed of exopolysaccharides (EPS), exogenous
DNA, and proteins that hold these communities together. P. aeruginosa produces lectins …
DNA, and proteins that hold these communities together. P. aeruginosa produces lectins …
Synthetic small molecules as anti-biofilm agents in the struggle against antibiotic resistance
B Parrino, D Schillaci, I Carnevale, E Giovannetti… - European journal of …, 2019 - Elsevier
Biofilm formation significantly contributes to microbial survival in hostile environments and it
is currently considered a key virulence factor for pathogens responsible for serious chronic …
is currently considered a key virulence factor for pathogens responsible for serious chronic …
Bacteria‐targeting photodynamic nanoassemblies for efficient treatment of multidrug‐resistant biofilm infected keratitis
Y Zhu, S Wu, Y Sun, X Zou, L Zheng… - Advanced Functional …, 2022 - Wiley Online Library
Multidrug‐resistant Pseudomonas aeruginosa (MDR‐P. aeruginosa) cannot be extirpated
with any of the antipseudomonal antibiotics available in clinic because P. aeruginosa exhibit …
with any of the antipseudomonal antibiotics available in clinic because P. aeruginosa exhibit …
A biomimetic non‐antibiotic approach to eradicate drug‐resistant infections
Y Zhao, Q Guo, X Dai, X Wei, Y Yu, X Chen… - Advanced …, 2019 - Wiley Online Library
The chronic infections by pathogenic Pseudomonas aeruginosa (P. aeruginosa) remain to
be properly addressed. In particular, for drug‐resistant strains, limited medication is …
be properly addressed. In particular, for drug‐resistant strains, limited medication is …
Hydroxyl groups in synthetic and natural-product-derived therapeutics: a perspective on a common functional group
J Cramer, CP Sager, B Ernst - Journal of medicinal chemistry, 2019 - ACS Publications
By forming extended hydrogen-bond networks, the contribution of hydroxyl groups to affinity
can reach several orders of magnitude. However, because of the high directionality of their …
can reach several orders of magnitude. However, because of the high directionality of their …
Thinking outside the box—novel antibacterials to tackle the resistance crisis
M Lakemeyer, W Zhao, FA Mandl… - Angewandte Chemie …, 2018 - Wiley Online Library
The public view on antibiotics as reliable medicines changed when reports about “resistant
superbugs” appeared in the news. While reasons for this resistance development are easily …
superbugs” appeared in the news. While reasons for this resistance development are easily …