Evolution of biofilm-forming pathogenic bacteria in the presence of nanoparticles and antibiotic: Adaptation phenomena and cross-resistance

R Mann, A Holmes, O McNeilly, R Cavaliere… - Journal of …, 2021 - Springer
Background Treatment of bacterial biofilms are difficult and in many cases, expensive.
Bacterial biofilms are naturally more resilient to antimicrobial agents than their free-living …

Enhanced antibacterial activity of repurposed mitomycin C and imipenem in combination with the lytic phage vB_KpnM-VAC13 against clinical isolates of Klebsiella …

O Pacios, L Fernández-García, I Bleriot… - Antimicrobial Agents …, 2021 - journals.asm.org
Klebsiella pneumoniae is an opportunistic Gram-negative pathogen that employs different
strategies (resistance and persistence) to counteract antibiotic treatments. This study aimed …

Antibiotic tolerance is associated with a broad and complex transcriptional response in E. coli

HS Deter, T Hossain, NC Butzin - Scientific reports, 2021 - nature.com
Antibiotic treatment kills a large portion of a population, while a small, tolerant subpopulation
survives. Tolerant bacteria disrupt antibiotic efficacy and increase the likelihood that a …

Real-time monitoring of Pseudomonas aeruginosa biofilm growth dynamics and persister cells' eradication

M Žiemytė, M Carda-Diéguez… - Emerging Microbes & …, 2021 - Taylor & Francis
Biofilm formation and the appearance of persister cells with low metabolic rates are key
factors affecting conventional treatment failure and antibiotic resistance. Using impedance …

[HTML][HTML] A quantitative survey of bacterial persistence in the presence of antibiotics: towards antipersister antimicrobial discovery

JE Salcedo-Sora, DB Kell - Antibiotics, 2020 - mdpi.com
Background: Bacterial persistence to antibiotics relates to the phenotypic ability to survive
lethal concentrations of otherwise bactericidal antibiotics. The quantitative nature of the time …

[HTML][HTML] Rethinking dormancy: Antibiotic persisters are metabolically active, non-growing cells

KMT Rahman, R Amaratunga, XY Butzin… - International Journal of …, 2025 - Elsevier
Objectives Bacterial persisters are a subpopulation of multidrug-tolerant cells capable of
surviving and resuming activity after exposure to bactericidal antibiotic concentrations …

Mechanisms for Rapid Evolution of Carbapenem Resistance in a Clinical Isolate of Pseudomonas aeruginosa

C Xu, D Wang, X Zhang, H Liu, G Zhu, T Wang… - Frontiers in …, 2020 - frontiersin.org
Infections by Pseudomonas aeruginosa are difficult to cure due to its high intrinsic and
acquired antibiotic resistance. Once colonized the human host, and thanks to antibiotic …

An isogenic E. coli population gives rise to multiple persister phenotypes

KMT Rahman, R Amaratunga, A Singh, T Hossain… - bioRxiv, 2023 - biorxiv.org
Bacterial persisters are a multidrug-tolerant subpopulation capable of surviving and
resuscitating after lethal antibiotic treatment, leading to relapsing infections and the …

Vibrio splendidus persister cells induced by host coelomic fluids show a similar phenotype to antibiotic‐induced counterparts

Y Li, TK Wood, W Zhang, C Li - Environmental microbiology, 2021 - Wiley Online Library
Persister cells are dormant variants of regular cells that are multidrug tolerant and have
heterogeneous phenotypes; these cells are a potential threat to hosts because they can …

Identification of a Toxin–Antitoxin System That Contributes to Persister Formation by Reducing NAD in Pseudomonas aeruginosa

J Zhou, S Li, H Li, Y **, F Bai, Z Cheng, W Wu - Microorganisms, 2021 - mdpi.com
Bacterial persisters are slow-growing or dormant cells that are highly tolerant to bactericidal
antibiotics and contribute to recalcitrant and chronic infections. Toxin/antitoxin (TA) systems …