MET signalling: principles and functions in development, organ regeneration and cancer
The MET tyrosine kinase receptor (also known as the HGF receptor) promotes tissue
remodelling, which underlies developmental morphogenesis, wound repair, organ …
remodelling, which underlies developmental morphogenesis, wound repair, organ …
Drug development of MET inhibitors: targeting oncogene addiction and expedience
The MET tyrosine kinase stimulates cell scattering, invasion, protection from apoptosis and
angiogenesis, thereby acting as a powerful expedient for cancer dissemination. MET can …
angiogenesis, thereby acting as a powerful expedient for cancer dissemination. MET can …
Tumour vascularization: sprouting angiogenesis and beyond
F Hillen, AW Griffioen - Cancer and Metastasis Reviews, 2007 - Springer
Tumour angiogenesis is a fast growing domain in tumour biology. Many growth factors and
mechanisms have been unravelled. For almost 30 years, the sprouting of new vessels out of …
mechanisms have been unravelled. For almost 30 years, the sprouting of new vessels out of …
Osteoclasts provide coupling signals to osteoblast lineage cells through multiple mechanisms
NA Sims, TJ Martin - Annual review of physiology, 2020 - annualreviews.org
Bone remodeling is essential for the repair and replacement of damaged and old bone. The
major principle underlying this process is that osteoclast-mediated resorption of a quantum …
major principle underlying this process is that osteoclast-mediated resorption of a quantum …
c-MET as a potential therapeutic target and biomarker in cancer
The receptor tyrosine kinase c-MET and its ligand, hepatocyte growth factor (HGF), regulate
multiple cellular processes that stimulate cell proliferation, invasion and angiogenesis. This …
multiple cellular processes that stimulate cell proliferation, invasion and angiogenesis. This …
The semaphorins: versatile regulators of tumour progression and tumour angiogenesis
G Neufeld, O Kessler - Nature Reviews Cancer, 2008 - nature.com
The semaphorins and their receptors, the neuropilins and the plexins, were originally
characterized as constituents of the complex regulatory system responsible for the guidance …
characterized as constituents of the complex regulatory system responsible for the guidance …
Tumor angiogenesis revisited: regulators and clinical implications
Abstract Since Judah Folkman hypothesized in 1971 that angiogenesis is required for solid
tumor growth, numerous studies have been conducted to unravel the angiogenesis process …
tumor growth, numerous studies have been conducted to unravel the angiogenesis process …
Targeting c-MET in gastrointestinal tumours: rationale, opportunities and challenges
CA Bradley, M Salto-Tellez, P Laurent-Puig… - Nature reviews Clinical …, 2017 - nature.com
Data from many preclinical studies, including those using cellular models of colorectal,
gastric, gastro-oesophageal and gastro-oesophageal junction cancers, indicate that the …
gastric, gastro-oesophageal and gastro-oesophageal junction cancers, indicate that the …
Semaphorins in health and disease
Cell-cell communication is pivotal to guide embryo development, as well as to maintain adult
tissues homeostasis and control immune response. Among extracellular factors responsible …
tissues homeostasis and control immune response. Among extracellular factors responsible …
Semaphorin signaling: progress made and promises ahead
Y Zhou, RAF Gunput, RJ Pasterkamp - Trends in biochemical sciences, 2008 - cell.com
Semaphorins were initially characterized according to their role in repulsive axon guidance
but are now recognized as crucial regulators of morphogenesis and homeostasis over a …
but are now recognized as crucial regulators of morphogenesis and homeostasis over a …