Most swimming bacteria are capable of following gradients of nutrients, signaling molecules
and other environmental factors that affect bacterial physiology. This tactic behavior became …

Growth rate maximization is an important fitness strategy for microbes. However, the wide
distribution of slow-growing oligotrophic microbes in ecosystems suggests that rapid growth …

Metabolic efficiency profoundly influences organismal fitness. Nonphotosynthetic organisms,
from yeast to mammals, derive usable energy primarily through glycolysis and respiration …

Nutrient scarcity is pervasive for natural microbial communities, affecting species
reproduction and co-existence. However, it remains unclear whether there are general rules …

Cancer cells rewire their metabolism to promote growth, survival, proliferation, and long-term
maintenance. The common feature of this altered metabolism is the increased glucose …

Genome‐scale metabolic models (GEM s) are widely used to calculate metabolic
phenotypes. They rely on defining a set of constraints, the most common of which is that the …

Overflow metabolism refers to the seemingly wasteful strategy in which cells use
fermentation instead of the more efficient respiration to generate energy, despite the …

The prediction of cellular function from a genotype is a fundamental goal in biology. For
metabolism, constraint-based modelling methods systematize biochemical, genetic and …

The economy of protein production is central to cell physiology, being intimately linked with
cell division rate and cell size. Attempts to model cellular physiology are limited by the …

Genome-scale metabolic models (GEMs) have been widely used for quantitative exploration
of the relation between genotype and phenotype. Streamlined integration of enzyme …