The optimal treatment for complex fractures and large bone defects is an important unsolved
issue in orthopedics and related specialties. Approximately 5–10% of fractures fail to heal …

Neutrophils are recognized as an essential part of the innate immune response, but an
active debate still exists regarding the life cycle of these cells. Neutrophils first differentiate in …

Bone is an active tissue, being constantly renewed in healthy individuals with participation of
the immune system to a large extent. Any imbalance between the processes of bone …

Recent research has brought about a clear understanding that successful fracture healing is
based on carefully coordinated cross-talk between inflammatory and bone forming cells. In …

The reconstitution of lost bone is a subject that is germane to many orthopedic conditions
including fractures and non-unions, infection, inflammatory arthritis, osteoporosis …

Osteoimmunology is at full display during endosseous implant osseointegration. Bone
formation, maintenance and resorption at the implant surface is a result of bidirectional and …

The widespread use of biomaterials to support or replace body parts is increasingly
threatened by the risk of implant‐associated infections. In the quest for finding novel anti …

Optimal fracture treatment requires knowledge of the complex physiological process of bone
healing. The course of bone healing is mainly influenced by fracture fixation stability …

More than 20 years ago, Wood et al.(Curr Anthropol 33: 343–370, 1992) published “The
Osteological Paradox: Problems of Inferring Prehistoric Health from Skeletal Samples,” in …

The transforming growth factor beta (TGF‐β) family forms a group of three isoforms, TGF‐β1,
TGF‐β2, and TGF‐β3, with their structure formed by interrelated dimeric polypeptide chains …