Lessons learned from clinical trials using antimicrobial peptides (AMPs)
GS Dijksteel, MMW Ulrich, E Middelkoop… - Frontiers in …, 2021 - frontiersin.org
Antimicrobial peptides (AMPs) or host defense peptides protect the host against various
pathogens such as yeast, fungi, viruses and bacteria. AMPs also display immunomodulatory …
pathogens such as yeast, fungi, viruses and bacteria. AMPs also display immunomodulatory …
[HTML][HTML] Mechanisms and consequences of bacterial resistance to antimicrobial peptides
Cationic antimicrobial peptides (AMPs) are an intrinsic part of the human innate immune
system. Over 100 different human AMPs are known to exhibit broad-spectrum antibacterial …
system. Over 100 different human AMPs are known to exhibit broad-spectrum antibacterial …
The antimicrobial peptide SAAP-148 combats drug-resistant bacteria and biofilms
A de Breij, M Riool, RA Cordfunke… - Science translational …, 2018 - science.org
Development of novel antimicrobial agents is a top priority in the fight against multidrug-
resistant (MDR) and persistent bacteria. We developed a panel of synthetic antimicrobial …
resistant (MDR) and persistent bacteria. We developed a panel of synthetic antimicrobial …
[HTML][HTML] Gram-positive bacterial cell envelopes: The impact on the activity of antimicrobial peptides
N Malanovic, K Lohner - Biochimica et Biophysica Acta (BBA) …, 2016 - Elsevier
A number of cationic antimicrobial peptides, effectors of innate immunity, are supposed to
act at the cytoplasmic membrane leading to permeabilization and eventually membrane …
act at the cytoplasmic membrane leading to permeabilization and eventually membrane …
Antimicrobial peptides targeting gram-positive bacteria
N Malanovic, K Lohner - Pharmaceuticals, 2016 - mdpi.com
Antimicrobial peptides (AMPs) have remarkably different structures as well as biological
activity profiles, whereupon most of these peptides are supposed to kill bacteria via …
activity profiles, whereupon most of these peptides are supposed to kill bacteria via …
[HTML][HTML] Antimicrobial peptides with selective antitumor mechanisms: prospect for anticancer applications
In the last several decades, there have been significant advances in anticancer therapy.
However, the development of resistance to cancer drugs and the lack of specificity related to …
However, the development of resistance to cancer drugs and the lack of specificity related to …
Advances in development of antimicrobial peptidomimetics as potential drugs
The rapid emergence of multidrug-resistant pathogens has evolved into a global health
problem as current treatment options are failing for infections caused by pan-resistant …
problem as current treatment options are failing for infections caused by pan-resistant …
[HTML][HTML] Current landscape in the discovery of novel antibacterial agents
J Vila, J Moreno-Morales… - Clinical Microbiology and …, 2020 - Elsevier
Background Standard treatments against bacterial infections are becoming ineffective due to
the rise of antibacterial resistance worldwide. Classical approaches to develop new …
the rise of antibacterial resistance worldwide. Classical approaches to develop new …
A review of antimicrobial peptides: its function, mode of action and therapeutic potential
S Nayab, MA Aslam, S Rahman, ZD Sindhu… - International Journal of …, 2022 - Springer
Antimicrobial peptides (AMPs) are endogenous polypeptides produced by multicellular
organisms in order to protect a host from pathogenic microbes. AMPs are also defined as …
organisms in order to protect a host from pathogenic microbes. AMPs are also defined as …
Strategies in translating the therapeutic potentials of host defense peptides
The golden era of antibiotics, heralded by the discovery of penicillin, has long been
challenged by the emergence of antimicrobial resistance (AMR). Host defense peptides …
challenged by the emergence of antimicrobial resistance (AMR). Host defense peptides …