Multiple APOBEC3 restriction factors for HIV-1 and one Vif to rule them all
BA Desimmie, KA Delviks-Frankenberrry… - Journal of molecular …, 2014 - Elsevier
Several members of the APOBEC3 family of cellular restriction factors provide intrinsic
immunity to the host against viral infection. Specifically, APOBEC3DE, APOBEC3F …
immunity to the host against viral infection. Specifically, APOBEC3DE, APOBEC3F …
Human APOBEC3 variations and viral infection
Human APOBEC3 (apolipoprotein B mRNA-editing catalytic polypeptide-like 3) enzymes
are capable of inhibiting a wide range of endogenous and exogenous viruses using …
are capable of inhibiting a wide range of endogenous and exogenous viruses using …
Suppression of APOBEC3-mediated restriction of HIV-1 by Vif
The APOBEC3 restriction factors are a family of deoxycytidine deaminases that are able to
suppress replication of viruses with a single-stranded DNA intermediate by inducing …
suppress replication of viruses with a single-stranded DNA intermediate by inducing …
Structural basis of HIV-1 Vif-mediated E3 ligase targeting of host APOBEC3H
Abstract Human APOBEC3 (A3) cytidine deaminases are antiviral factors that are
particularly potent against retroviruses. As a countermeasure, HIV-1 uses a viral infectivity …
particularly potent against retroviruses. As a countermeasure, HIV-1 uses a viral infectivity …
Natural polymorphisms in human APOBEC3H and HIV-1 Vif combine in primary T lymphocytes to affect viral G-to-A mutation levels and infectivity
The Vif protein of HIV-1 allows virus replication by degrading several members of the host-
encoded APOBEC3 family of DNA cytosine deaminases. Polymorphisms in both host …
encoded APOBEC3 family of DNA cytosine deaminases. Polymorphisms in both host …
HIV-1 Vif adaptation to human APOBEC3H haplotypes
M Ooms, B Brayton, M Letko, SM Maio, CD Pilcher… - Cell host & …, 2013 - cell.com
Several human APOBEC3 deaminases can inhibit HIV-1 replication in vitro. HIV-1 Vif
counteracts this restriction by targeting APOBEC3 for proteasomal degradation. Human …
counteracts this restriction by targeting APOBEC3 for proteasomal degradation. Human …
Structure-guided analysis of the human APOBEC3-HIV restrictome
H Aydin, MW Taylor, JE Lee - Structure, 2014 - cell.com
Human APOBEC3 (A3) proteins are host-encoded intrinsic restriction factors that inhibit the
replication of many retroviral pathogens. Restriction is believed to occur as a result of the …
replication of many retroviral pathogens. Restriction is believed to occur as a result of the …
Structural insights into APOBEC3-mediated lentiviral restriction
KA Delviks-Frankenberry, BA Desimmie, VK Pathak - Viruses, 2020 - mdpi.com
Mammals have developed clever adaptive and innate immune defense mechanisms to
protect against invading bacterial and viral pathogens. Human innate immunity is …
protect against invading bacterial and viral pathogens. Human innate immunity is …
Understanding the structure, multimerization, subcellular localization and mC selectivity of a genomic mutator and anti-HIV factor APOBEC3H
Abstract APOBEC3H (A3H) is a member of the APOBEC3 subfamily of DNA cytosine
deaminases that are important for innate immune defense and have been implicated in …
deaminases that are important for innate immune defense and have been implicated in …
Natural polymorphisms and oligomerization of human APOBEC3H contribute to single-stranded DNA scanning ability
APOBEC3H is a deoxycytidine deaminase that can restrict the replication of HIV-1 in the
absence of the viral protein Vif that induces APOBEC3H degradation in cells. APOBEC3H …
absence of the viral protein Vif that induces APOBEC3H degradation in cells. APOBEC3H …