Lysine degradation via formation of saccharopine is a pathway confined to the mitochondria.
The second pathway for lysine degradation, the pipecolic acid pathway, is not yet fully …

The saccharopine pathway (SACPATH) involves the conversion of lysine into α-
aminoadipate by three enzymatic reactions catalyzed by the bifunctional enzyme lysine …

Accumulating evidence suggests that ketogenic diets (KDs) mediate the rise of circulating
ketone bodies and exert a potential anti-inflammatory effect; however, the consequences of …

Brain hemispheres are connected by commissural structures, which consist of white matter
fiber tracts that spread excitatory stimuli to various regions of the cortex. This allows an …

Zn2+ is required for the activity of many mitochondrial proteins, which regulate mitochondrial
dynamics, apoptosis and mitophagy. However, it is not understood how the proper …

Organisms respond to tissue damage through the upregulation of protective responses
which restore tissue structure and metabolic function. Mitochondria are key sources of …

The development of antibacterial resistance imposes the development of novel materials to
relieve the burden of infection. Chitosan, a material of natural and sustainable origin …

Abstract d-2-Hydroxyglutarate (D-2HG) is an α-ketoglutarate-derived mitochondrial
metabolite that causes d-2-hydroxyglutaric aciduria, a devastating developmental disorder …

Lysine is an essential amino acid that serves as a building block in protein synthesis. Beside
this, the metabolic activity of lysine has only recently been unraveled. Lysine metabolism is …

Background The prevalence of age-related disorders, particularly in neurological and
cardiovascular systems, is an increasing global health concern. Mesenchymal stem cell …